By Terry F. Davies
In A Case-Based Guide to Clinical Endocrinology, Second version, a popular workforce of distinctive clinicians once back offers stimulating instruction and insights into a wide selection of endocrine topics, teaching readers modern administration of the stipulations defined and offering distinct access into the literature. Importantly, a number of the vital parts within the present curriculum for scientific endocrine education as instructed through the organization of application administrators in scientific Endocrinology, Diabetes and Metabolism are lined during this textual content. completely up to date, this re-creation not just covers new therapy techniques but additionally emphasizes the newest investigative advances in either imaging and molecular diagnostics. to augment studying and retention of information, a question-based process is utilized in some of the case stories. scholars, citizens, fellows, and practitioners will locate this connection with be a good approach to overview their understanding and bring up their skills and abilities in sufferer research and administration. a useful contribution to the sector, A Case-Based Guide to Clinical Endocrinology, Second Edition, deals an analogous comprehensive volume of thought-provoking case-studies that made the 1st variation of vital value to all clinicians who deal with sufferers with endocrine disorders.
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Extra info for A Case-Based Guide to Clinical Endocrinology
Which of the following is the most accurate interpretation of her assessment? (A) Patient has irregular menses due to intense exercise (B) IGF-1 and post-glucose GH nadir are above normal range for a 28-year-old woman and suggestive of acromegaly (C) IGF-1 is elevated, but post-glucose nadir levels are normal; thus the patient does not have acromegaly (D) She needs repeat testing after she is started on estrogen progesterone treatment to normalize her menses 2. A patient presented with several signs and symptoms suggestive of acromegaly.
This patient had a history of amenorrhea and intermittent unexplained vaginal bleeding, which is a contraindication for the use of mifepristone. She was subsequently treated with pasireotide (Signifor), a somatostatin receptor ligand, which has a high affinity for SSTR5. It has inhibitory effects on ACTH secretion in the corticotrophic cells and has been shown to normalize cortisol levels in up to 50 % of patients with mild CD. The main side effect with this therapy is hyperglycemia. Other adverse effects are similar to the other somatostatin analogues.
J Clin Endocrinol Metab. 2008;93:2454–62. G. Yedinak et al. 3. Boscaro M, Arnaldi G. Approach to the patient with possible Cushing’s syndrome. J Clin Endocrinol Metab. 2009;94:3121–31. 4. Colao A, De Block C, Gaztambide MS, Kumar S, Seufert J, Casanueva FF. Managing hyperglycemia in patients with Cushing’s disease treated with pasireotide: medical expert recommendations. Pituitary. 2014;17(2):180–6. 5. Colao A, Petersenn S, Newell-Price J, Findling JW, Gu F, Maldonado M, et al. A 12-month phase 3 study of pasireotide in Cushing’s disease.
A Case-Based Guide to Clinical Endocrinology by Terry F. Davies