Download PDF by Francis S., MD Greenspan (Editor), Gordon J., MD Strewler: Basic Clinical Endocrinology

By Francis S., MD Greenspan (Editor), Gordon J., MD Strewler (Editor)

ISBN-10: 0071440119

ISBN-13: 9780071440110

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Analysis of inherited monogenic diseases has been greatly facilitated by linkage maps of every human chromosome and by DNA sequence data, which helps track a particular disease-causing allele through affected families. Many inherited syndromes, such as defects in steroid biosynthesis (Chapters 10, 13, 14, 15, and 16) are often the result of a single monogenic mutation. More common diseases such as hypertension (Chapter 11) and type 2 diabetes mellitus (Chapter 18) also have genetic components but are thought to result from the interplay of several common genetic variants (polygenic disease).

This provided a means for delivery of substances more generally than with the nervous systems, which developed axons to deliver a paracrine signal. Hormone-producing organs became either relatively specialized, as in the case with the classical glands (eg, pituitary, adrenal, thyroid), the subdivisions of other glands (pancreatic islets), or part of an organ with other major functions (eg, heart, kidney, fat). Within these glands, additional specialization evolved such that specialized cells release specific hormones (eg, in the anterior pituitary, lactotrophs release PRL and somatotrophs release GH; in the pancreatic islets, -cells release insulin and -cells release glucagon).

Immunosuppression is most pronounced in the second and third trimesters and rebounds by about 3รข 6 months postpartum. Central Nervous System The endocrine and nervous systems interact in multiple ways (see Chapter 5), and examples of this have been provided in the preceding sections. Hormones regulate behavioral and cognitive functions such as mood, appetite, learning, memory, and sexual activity. Hormones also have secondary influences on the central nervous system through effects on general metabolism.

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Basic Clinical Endocrinology by Francis S., MD Greenspan (Editor), Gordon J., MD Strewler (Editor)


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