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By Anthony N. Laskovski

ISBN-10: 9533075139

ISBN-13: 9789533075136

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Chem Eng J 2010; 160: 378-382. Liu BS, Yao CH, Fang SS. Evaluation of a non-woven fabric coated with a chitosan bi-layer composite for wound dressing. Macromol Biosci 2008; 8: 432-440. Loke WK, Lau SK, Yong LL, Khor E, Sum CK. Wound dressing with sustained antimicrobial capability. J Biomed Mater Res Appl Biomater 2000; 53: 8-17. Lu G, Ling K, Zhao P, Xu Z, Deng C, Zheng H, Huang J, Chen J. A novel in situ-formed hydrogel wound dressing by the photocross-linking of a chitosan derivative. Wound Rep Reg 2010; 18: 70-79.

Jayakumar R, Nwe N, Tokura S, Tamura H. Sulfated chitin and chitosan as novel biomaterials. Int J Biol Macromol 2007; 40: 175-181. Jayakumar R, Prabaharan M, Nair SV, Tamura H. Novel chitin and chitosan nanofibers in biomedical applications. Biotech Adv 2010c; 28: 142-150. Jayakumar R, Prabaharan M, Nair SV, Tokura S, Tamura H, Selvamurugan N. Novel carboxymethyl derivatives of chitin and chitosan materials and their biomedical applications. Prog Mater Sci 2010d; 55: 675-709. Jayakumar R, Prabaharan M, Reis RL, Mano JF.

They found that LMWC (21 and 46 kDa) and also smaller oligosaccharides could activate the intestinal immune system of animals, thus preventing tumour growth. But no antitumour effect was observed after the oral administration of chitosan samples, even of low molecular weight (46 kDa). The same authors confirmed that high molecular weight chitosan (650 kDa) prevents the adverse reactions of some cancer chemotherapeutic drugs. Qin et al. also tested the antitumour activity of LMWC against sarcoma 180, but they came to the opposite conclusions.

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Biomedical Engineering, Trends in Materials Science by Anthony N. Laskovski


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