Biotechnology of Isoprenoids by Jens Schrader, Jörg Bohlmann PDF

By Jens Schrader, Jörg Bohlmann

ISBN-10: 3319201069

ISBN-13: 9783319201061

ISBN-10: 3319201077

ISBN-13: 9783319201078

This publication assessment sequence offers present developments in sleek biotechnology. the purpose is to hide all points of this interdisciplinary expertise the place wisdom, tools and services are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and machine technology. Volumes are geared up topically and supply a finished dialogue of advancements within the respective box over the last 3-5 years. The sequence additionally discusses new discoveries and purposes. unique volumes are devoted to chosen themes which concentrate on new biotechnological items and new procedures for his or her synthesis and purification. in most cases, detailed volumes are edited through recognized visitor editors. The sequence editor and writer will notwithstanding constantly be happy to obtain feedback and supplementary info. Manuscripts are accredited in English.

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1) meroterpenoid biosynthetic pathway from A. fumigatus in A. oryzae [59] identified a protein (Pyr4) predicted to be an integral membrane protein as farnesyl cyclase. This protein is unusually small (242 aa) and does not share any homology with known proteins in the National Center for Biotechnology Information (NCBI) database. It also lacks the aspartate-rich motifs commonly found in prenyl transferases and cyclases. g. g. PaxB, AtmB, LtmB) biosynthetic gene clusters. Each of these clusters also encodes an FAD-dependent monooxygenase.

Furthermore, although filamentous fungi tend to have between 20 and 50 NRPS and PKS biosynthetic gene clusters in their genomes [38], Basidiomycota typically have fewer than 10 PKS or NRPS genes, of which only a few have been expressed and characterized [16, 24, 25, 97–99]. These surveys indicate that Ascomycota and Basidiomycota may have evolved different arsenals of natural products. Ascomycota seem to rely on PK, NRP, and indole-derived compounds as their predominant natural product classes, while terpenoids are the major class made by Basidiomycota.

Illudane-type sesquiterpenoids are among the best-known bioactive compounds made by Basidiomycota. They exhibit potent antitumor, antiviral, and antibacterial activity [147–152] and have been isolated from several mushrooms [153–166]. Omphalotus olearius was identified decades ago as a prolific producer of anticancer illudin M and S [152, 167–169]. Illudins are derived from the protoilludane scaffold (Fig. 6). We aimed to identify the corresponding sesquiterpene synthase and expected surrounding genes encoding the illudin biosynthetic pathway.

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Biotechnology of Isoprenoids by Jens Schrader, Jörg Bohlmann

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