By Charles G. D. Brook, Peter Clayton, Rosalind Brown
A benchmark reference textbook.
a great editorial staff and across the world popular individuals come jointly to convey you Brook’s scientific Pediatric Endocrinology . This new ebook is filled with sensible recommendation and is vital studying for everybody interested in the care of kids and children with endocrine affliction and problems.
This striking reference publication has been absolutely up-to-date to add new innovations, new investigations and new molecular mechanisms and is filled with sensible, scientific advice. The ideal textual content for pediatric endocrinologists, endocrinologists and pediatricians.
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Additional info for Brook's Clinical Pediatric Endocrinology
1). Recruitment of a particular Gα-subunit depends on many factors , including receptor subtype (Fig. 6a), structural features of the cytoplasmic domain and the concentration of the ligand. For example, at low concentrations, TSH, calcitonin and luteinizing hormone (LH)/human chorionic gonadotropin (hCG) receptors activate adenylate cyclase through Gαs, whereas at higher concentration, Gαq is recruited to activate PLC. Further complexity is introduced by the potential for receptors simultaneously or successively to couple with distinct G-proteins (Fig.
These are located either at the cell surface or within intracellular compartments, such as the cytoplasm and nucleus. Receptor location, which forms the basis of their classification into subgroups (Fig. 1), reflects ligand characteristics. Receptors for hydrophilic hormones, such as the pituitary-derived proteins, insulin and the catecholamines, are present at the plasma membrane; lipid-soluble steroid and thyroid hormones cross this barrier to access intracellular binding sites. Receptors are specific and usually have a high affinity for their particular ligand but the forces involved in ligand–receptor binding (ionic attractions, van der Waals forces, hydrogen bonding or hydrophobic interactions) are weak.
Genes IX. Oxford: Jones and Bartlett Publishers, 2008. Manolio TA, Bailey-Wilson JE, Collins FS. Genes, environment and the value of prospective cohort studies. Nat Rev Genet 2006; 7: 812– 820. Manolio TA, Brooks LD, Collins FS. A HapMap harvest of insights into the genetics of common disease. J Clin Invest 2008; 118: 1590–1605. Mardis ER. Next-generation DNA sequencing methods. Annu Rev Genomics Hum Genet 2008; 9: 387–402. Nielsen R, Williamson S, Kim Y, et al. Genomic scans for selective sweeps using SNP data.
Brook's Clinical Pediatric Endocrinology by Charles G. D. Brook, Peter Clayton, Rosalind Brown