Cellular Mechanisms of Renal Tubular Ion Transport - download pdf or read online

By Felix Bronner and Arnost Kleinzeller (Eds.)

ISBN-10: 0080584845

ISBN-13: 9780080584843

ISBN-10: 0121533131

ISBN-13: 9780121533137

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The effects on the time course of pH, of the simultaneous movements of both members of a conjugate pair of a weak acid or base have been described mathematically (6). Just as exposure to NH: leads to a rapid intracellular alkalinization, exposure to CO, causes a rapid, reversible acidification. This was first clearly demonstrated in 1920 by Jacobs (26 1, who pointed out that when CO, is introduced, it rapidly enters the cell where it then becomes hydrated and dissociates to form H+ and HCO,. Removal of CO, should lead to a reversal of this process, causing pH, to return toward its initial level.

1920). The production of intracellular acidity by neutral and alkaline solutions containing carbon dioxide. A m . J. Phgsiol. 53,457-463. 27. Knauf, P. , and Rothstein, A. (1971). Chemical modification of membranes. I . Effects of sulfhydryl and amino reactive agents on anion and cation permeability of the human red blood cell. J . Gun. Physiol. 58, 190-210. 28. Kostyuk, P. G.. and Sorokina, Z. A. (1961). On the mechanism of hydrogen ion distribution between cell protoplasm and the medium. I n ”Membrane Transport Metabolism“ (A.

Waddell, W. , and Bates, R. G. Intracellular pH. Physiol. R e v . 49, 185-329. 40. Waddell, W. , and Butler, T. C. (1959). Calculation of intracellular pH from the (DMO). Application to skeletal musdistribution of 5,5-dimethyl-2,4-oxazolidinedione cle of dog. J. Clin. Invest. 38, 720-729. 41. J. Studies on carbonic acid compounds and hydrogen ion activities in blood and salt solutions. A contribution to the theory of the equation of Lawrence J. Henderson and K. A. Hasselbalch. Biochem. J. 16, 153-340.

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Cellular Mechanisms of Renal Tubular Ion Transport by Felix Bronner and Arnost Kleinzeller (Eds.)


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