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Extra info for Cytology - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
The ZW1O protein displays an unusual, dynamic pattern of localization during the cell cycle, moving between chromosomal kinetochores and kinetochore microtubules. We found that this pattern is influenced by bipolar tension across individual chromosomes. We also discovered that ZW1O is part of a large protein complex, one of whose activities is to target the Studies 25 molecular motor dynein to the kinetochore. We will use real-time video microscopy to characterize the distribution of a ZW1O-GFP fusion protein during the cell cycle.
This evidence has generated an intense debate about the choice of ventilator settings for patients with injured lungs and has fueled research on the mechanisms of ventilator-induced lung injury (VILI). The number of mechanisms and the complex interplay between them complicate analyses of experiments on whole lungs. For this reason, we propose to test our principal hypothesis (that deformation represents a pro-inflammatory stimulus for epithelial and endothelial lung cells) in whole organ as well as in reduced systems.
The CSF cytology, MRI, thyroid, hematology and neuropsychology profiles and neurological status will be followed up to 6 months and contrasted with dosages and dosimetry to determine a reliable set of parameters for further studies. At the end of the study period, our team shall have generated a sufficient set of data to determine whether it is worthwhile to pursue a phase II clinical trial of intrathecal I-131 NaI for the treatment of LM. ; Professor; Surgery; University of California Irvine Irvine, Ca 926977600 Timing: Fiscal Year 2002; Project Start 01-MAY-1982; Project End 31-JUL-2004 Summary: The long term objective of this project is the development of Photodynamic Therapy (PDT) for application in the clinical management of patients with cancer.
Cytology - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications