By Lewis E. Braverman
This widely revised and up-to-date variation of a favored and broadly acclaimed paintings offers the newest clinical and medical advancements in thyroid disorder. New subject matters comprise the medical relevance of the sodium/iodide symporter (NIS), large assurance of autoimmune thyroid disorder, and elevated assurance of thyroid melanoma, together with recombinant human TSH. different chapters talk about thyroid disorder while pregnant and postpartum, thyroid affliction in teenagers and the aged, and the evaluate and administration of nodular goiter. ailments of the Thyroid, 2d variation, presents internists and relatives physicians, obstetricians and gynecologists, and endocrinologists alike with a hugely readable advisor to thyroid problems and their scientific administration.
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Additional resources for Diseases of the Thyroid (Contemporary Endocrinology)
It is also desirable to identify relevant hormone-specific binding sites in the system in which a nongenomic event has been described. We have also excluded a genomic contribution in certain of our own studies by using TH analogs, such as 22 Davis and Davis tetrac, that have virtually no intrinsic biologic activity at TRs, but are capable of inhibiting putative nongenomic actions of the hormone (3,12,22). SPECIFIC NONGENOMIC ACTIONS OF THYROID HORMONE Actions of Thyroid Hormone at the Cell Membrane Functions of the plasma membrane include solute transport and regulation of selective permeability (ion channels), reception of primary messenger molecules at specific receptors, signal transduction, presentation of molecules with metabolic roles (such as enzymes) at the cell surface, and interaction of the cell surface with molecules in the extracellular matrix (ECM).
Arnold S, Goglia F, Kadenback B. 3,5-Diiodothyronine binds to subunit Va of cytochrome-c oxidase and abolishes the allosteric inhibition of respiration by ATP. Eur J Biochem 1998;252:325–330. 33. Mason GA, Walker CH, Prange AJ Jr. Depolarization-dependent 45Ca uptake by synaptosomes of rat cerebral cortex is enhanced by L-triiodothyronine. Neuropsychopharmacology 1990;3:291–295. 34. Lin H-Y, Martino LJ, Wilcox BD, Davis FB, Gordinier JK, Davis PJ. Potentiation by thyroid hormone of human IFN-γ-induced HLA-DR expression.
The structure–activity relationships for hormone analogues in the erythrocyte model have been extensively studied (7); T4 is more active than T3, rT3 and D-analogues are without effect, and 3,5-dimethyl-3′-isopropylL-thyronine (DIMIT) is active. Tetraiodothyroacetic acid (tetrac) is inactive, but blocks the action of T4 (3,12,36). Chapter 2 / Nongenomic Actions of Thyroid Hormone 25 The calmodulin–Ca2+ complex is the principal intracellular regulator of Ca2+–ATPase activity (68). The TH effect on Ca2+–ATPase requires the presence of calmodulin (15), and pharmacologic antagonists of calmodulin inhibit the stimulation of the enzyme by TH (15,16).
Diseases of the Thyroid (Contemporary Endocrinology) by Lewis E. Braverman