Read e-book online Endocrinology: An Integrated Approach PDF

By S.S. Nussey, S.A. Whitehead

ISBN-10: 1859962521

ISBN-13: 9781859962527

Commonly, endocrinology textbooks were both brief notes or multi-author, multi-volume monster, all of which current scientific fabric final and sometimes merely in brief. Endocrinology is diversified and used genuine circumstances to guide readers into the textual content after which describes the biochemistry, body structure, and anatomy they should comprehend the case. The easy layout makes use of colour-coded containers to focus on the elemental medical and scientific fabric required and in addition to explain the newest extra complex evidence.

Typical scientific instances are incorporated, in addition to extra idiosyncratic situations to seize realization and spotlight the cross-disciplinary nature of drugs. Endocrinology is the 1st ebook to handle the requirement for built-in simple technology and scientific perform, to motivate problem-based studying, and to steer readers deep into the subject.

Unique benefits:
* integrates fundamentals sciences and medical practice
* positive aspects extra genuine medical circumstances than any comparable booklet to stress problem-based learning
* complete and but approachable
* features a accomplished diversity of questions and solutions to check knowing

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Extra resources for Endocrinology: An Integrated Approach

Example text

Novel somatic mutations may present with expression only within specific tissues. Clinical examples of the effects of mutations are given in the text where appropriate. Animal models (predominantly rodent) have also provided an enormous insight into endocrine diseases. Some of these mouse and rat strains were the result of naturally occurring mutations. More recently genes have been experimentally inserted (transgenic) or deleted (knockout) in mice and these animal models have provided considerable scientific knowledge.

There is also evi- dence that cytokines act directly on endocrine glands such as the pituitary, thyroid, pancreas, adrenals and gonads and alter their secretions. Pituitary hormones and the secretions of their peripheral target endocrine glands may modulate immune function. Thus, for example, ACTH/glucocorticoids are immunosuppressants as are progesterone and testosterone whilst the action of estrogens is both stimulatory and inhibitory. 16). 16: Overview of interactions between the endocrine and immune systems and feedback effects of immunomodulatory peptides and hormones on the hypothalamo-pituitary axis and on peripheral endocrine glands released by macrophages, stimulates the secretion of hypothalamic CRH release.

Thus, whatever the catabolic fate of proteins, they are all energy-producing pathways. Insulin promotes the uptake of amino acids (especially the essential amino acids leucine, valine, isoleucine, tyrosine and phenylalanine) into muscle and stimulates protein synthesis. Simultaneously, it prevents protein breakdown and the release of certain amino acids from muscle. 6). 12). 11: Peroxisome proliferator-activated receptors (PPARs) • T h e 3 PPARs ( α , β, γ) are all activated by naturally occurring fatty acids o r fatty acid derivatives.

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Endocrinology: An Integrated Approach by S.S. Nussey, S.A. Whitehead


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