Download e-book for iPad: Estrogens and Brain Function: Neural Analysis of a by Donald W. Pfaff (auth.)

By Donald W. Pfaff (auth.)

ISBN-10: 1461380847

ISBN-13: 9781461380849

ISBN-10: 1461380863

ISBN-13: 9781461380863

This ebook brings jointly a number of the effects and ideas produced by way of numerous people-colleagues and scholars with whom i'm privileged to paintings within the laboratory at Rockefeller collage. by way of my own heritage I see it as a confluence of inventive forces­ people from whom i've got discovered. i used to be advised in neuroanatomy by way of Walle J. H. Nauta at M. I. T. , and later in a direction at Harvard clinical university less than the path of Richard Sidman. At Harvard scientific institution, the place M. I. T. graduate scholars have been allowed to pass sign in, the wonderful neurophysiology path was once below the guiding spirit of Stephen Kuffler. Later, I benefited enormously from engaging in his summer season direction in electrophysiological options at Woods gap. Eric Kandel and his colleagues have supplied us with the main interesting modern method of the conceptualization and research of mobile mechanisms for habit. right here at Rockefeller, Carl Pfaffmann and Neal Miller were leaders in each feel of the be aware. not just did they supply me with possibilities to develop to clinical adulthood; additionally they set an instance of transparent brooding about mechanisms for mammalian habit styles. I wrote this e-book to teach how the systematic use of more and more particular electrophysiological, neuroanatomical, and neuroendocrine tech­ niques can clarify the mechanism for a mammalian behavioral reaction. The habit in query occurs to be delicate to steroid hormones and performs a vital function in reproduction.

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Additional info for Estrogens and Brain Function: Neural Analysis of a Hormone-Controlled Mammalian Reproductive Behavior

Sample text

Input from other skin regions on the female rat important for lordos- A . - ... -"r... ----. '----,>---". .. " . r-.. ","--_ ~""'-rt , Figure 3 -2. Effect of severing pudendal nerve on dorsal root multiunit responses: recordings of dorsal root L6 • (A) Before pudendal nerve was severed. (B) After pudendal nerve was severed. Thickened portions of time marker lines: skin within the pudendal nerve receptive field was brushed. The dorsal root response to skin stimulation occurred before (A) but not after (B) the pudendal nerve was cut.

Dotted line (in Tn through L2): extent of the separation of skin from the underlying tissues due to the dorsal approach to the cord for electrode insertion. For L3 , the largest (dotted line) and smallest (dashed line) examples of receptive field size are superimposed on the representative field (shaded area). The 13th rib is the most posterior rib. The crest of the ilium is indicated. (From Kow & Pfaff, 1975b) medial half of the spinal gray, while units with receptive fields on the proximal or dorsal parts of a dermatome tended to be located in the lateral half of the spinal gray (Table 4-1).

M 800~ n B ::: E 400 ~- 0- 0 '" eoof j~ 400t o c --------------~ L_ Figure 4 -3 A -co Responses of pressure-sensitive neurons recorded in the spinal cord. (A) Most of these units were excited by pressure on the skin. (B) Some responses outlasted the stimulus. (C) A few units were inhibited by cutaneous pressure. , 1980b) excited by pressure (Figure 4-3A, B). When continuously increasing pressure on the receptive field of such units reached a threshold level, their firing rate would increase to a plateau level, which then was maintained despite further increases in pressure.

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Estrogens and Brain Function: Neural Analysis of a Hormone-Controlled Mammalian Reproductive Behavior by Donald W. Pfaff (auth.)


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