Download e-book for kindle: Focus on Homocysteine and the Vitamins: Involved in its by Christina Bolander-Gouaille

By Christina Bolander-Gouaille

ISBN-10: 2287597123

ISBN-13: 9782287597121

ISBN-10: 2817808452

ISBN-13: 9782817808451

During the final 10-12 years, the study on homocysteine has develop into very lively. approximately 1500 of articles are actually released every year on homocysteine and the supplementations curious about its metabolism. A disturbed homocysteine metabolism might be an underlying issue for being pregnant issues and fetal malformations, heart problems, dementia, psychiatric and neurologic problems and doubtless carcinogenesis. A disturbed homocysteine metabolism can mostly be normalised through therapy with folate and/or vitamines B12 and B6. a lot of those findings for this reason at once predicament such a lot practitioners. despite the fact that, if there are reliable studies masking unmarried points of this study, those are released in specialized journals. the writer has realised the problems for the practitioner in maintaining up-to-date. This moment version has been completely up-to-date and in addition deals extra info at the supplementations. Over 1600 references are made available.

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2000) • Inhibition of growth of vascular endothelial cells associated with decreased DNA methylation (Wang H et al. 1997, Chen CY et al. 2000) and specific changes in gene expression (Outinen et al. 1999) • Promotion of smooth muscle cell proliferation (Tsai JC et al. 1994, Carmody et al. 1999, Chen CY et al. 2ooo, Woo DK et al. 2000), an effect counteracted by folic acid (Carmody et al. 1999) • CoUagen accumulation (Majors et al. 1997, Tygai et al. 1998a,b) possibly caused by the induction of metalloproteinases-1 (Rodriguez JA et al.

This suggests that some of the adverse effects of homocysteine, which are related to arachidonic acid metabolism, may depend on the formation of thromboxane A2 , a potent vasoconstrictor and inducer of platelet aggregation. Total Hcy was also related to neopterin (a monocyte-derived inflammatory mediator) and endothelin-1, bothin patients with disturbed glucose metabolism and in controls, which again suggests an influence of Hcy on vascular function through interference with endothelial and leucocyte function {Gottsaker et al.

1999). The effect of PML-induced hyperhomocysteinaemia on cerebrovascular reactivity (CVR), which has been reported to be NO-related in experimental studies, was measured by transcranial Doppler ultrasonography in healthy younger and older adults before and after treatment with the angiotensin-converting enzyme inhibitor, quinapril (10 mg/day for 1 week). Before quinapril treatment, the increase in flow velocity in the middle cerebral artery after brief carotid compression was preserved PML in the younger subjects, but decreased in the older adults.

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Focus on Homocysteine and the Vitamins: Involved in its metabolism by Christina Bolander-Gouaille


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