By Paul G. Pearson, Larry C. Wienkers
This well timed, improved re-creation is the definitive guide for knowledgeable drug metabolism and pharmaceutical scientists and people new to the field.Written via across the world well known authors, it offers built-in, finished assurance of primary features of drug metabolism and the sensible purposes that aid consultant researchers via key demanding situations in smooth drug discovery and improvement.
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Extra resources for Handbook of Drug Metabolism
104. Gelboin HV, Krausz K. Monoclonal antibodies and multifunctional cytochrome P450: drug metabolism as paradigm. J Clin Pharmacol 2006; 46:353–372. 105. Haining RL, Nichols-Haining M. Cytochrome P450-catalyzed pathways in human brain: metabolism meets pharmacology or old drugs with new mechanism of action? Pharmacol Ther 2007; 113:537–545. 106. Schuster I, Bernhardt R. Inhibition of cytochromes p450: existing and new promising therapeutic targets. Drug Metab Rev 2007; 39:481–499. 107. Juliano RL, Ling V.
Interactions between CAR and PXR have recently been reviewed (97). The crystal structure of the human PXR ligand-binding domain in the presence and absence of ligands has been reported (98,99). INHIBITORS Compounds that had broad specificity as inhibitors of P450 played a major role in the understanding of this class of enzymes. The discovery of SKF525a in the laboratories of SKF and its expanded use by Brodie and coworkers defined the microsomal oxidases before the discovery of P450 (100,101).
Jollow DJ, Mitchell JR, Potter WZ, Davis DC, Gillette JR, Brodie BB. Acetaminopheninduced hepatic necrosis. II. Role of covalent binding in vivo. J Pharmacol Exp Ther 1973; 187(1):195–202. 37. Mitchell JR, Jollow DJ, Potter WZ, Davis DC, Gillette JR, Brodie BB. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharmacol Exp Ther 1973; 187(1):185–194. 38. Mitchell JR, Jollow DJ, Potter WZ, Gillette JR, Brodie BB. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.
Handbook of Drug Metabolism by Paul G. Pearson, Larry C. Wienkers