By Younggil Kwon
This quantity offers a prime computer reference and includes easy-to-understand suggestions for pharmacokinetics/pharmodynamics concerns, examine layout, and knowledge interpretation. PK/PD are vital elements for investigating the disposition and pharmacological efficacy of substances lower than a variety of experimental and scientific stipulations.
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Additional resources for Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists
A. J. Pharm. Sci. 87: 901 -903, 1998. Humphreys W. G. , Continuous blood withdrawal as a rapid screening method for determining clearance and oral bioavailability in rats, Pharm. Res. 15: 1257-1261, 1998. , Strategies and recent technologies in drug discovery, Pharmazie50: 647-662. 1995. Kuo B-S. , Sample pooling to expedite bioanalysis and pharmacokinetic research, J. Pharm. Biomed. 1998. Olah T. V. , The simultaneous determination of mixtures of drug candidates by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry as an in vivo drug screening procedure, Rapid Commun.
T1/2 after multiple dosing is dictated by the true terminal t 1/2 after single dosing. It is not uncommon to see the apparent t1/2 of a drug after multiple doses being longer than that after a single dose. This can be simply because the true terminal t1/2 after a single dose cannot be readily measured owing to assay limitations and/or inadequate sampling time points (Fig. 15). Time to reach steady state after multiple dosing. 14. Plasma drug concentration profiles of drugs A and B with the same EC50.
The size of the dose and the dosing interval determine the extent of the steady state drug concentrations after multiple dosing, depending on clearance of the drug but not on the time to reach the steady state. NOTE: ACCUMULATION FACTOR AFTER MULTIPLE DOSING. The accumulation factor (R) reflects how much drug is accumulated in the body at steady state after multiple dosing as compared to that after single dosing. The value of R can be estimated by dividing AUC over the dosing interval at steady state after multiple dosing (AUCss) divided by AUC from 0 to (AUC 0 - ) after the first dose.
Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists by Younggil Kwon