By Stephen Gough
This concise guide offers an outline of incretin-based treatments and assistance for incorporating them into the therapy of kind 2 diabetes. Chapters contain landmark scientific trials and foreign therapy guidance for you to replace readers with all significant advances within the box. a great source for doctors that deal with sufferers with sort 2 diabetes in medical institution and scientific settings.
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Extra resources for Handbook of Incretin-based Therapies in Type 2 Diabetes
Curr Med Res Opin. 2008;24:275-286. Fineman MS, Mace KF, Diamant M, et al. Clinical relevance of anti-exenatide antibodies: safety, efficacy and cross-reactivity with long-term treatment. Diabetes Obes Metab. 2012;14:546-554. Agerso H, Jensen LB, Elbrond B, Rolan P, Zdravkovic M. The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men. Diabetologia. 200245:195-202. 42 • HA ND B O O K O F I N C R E T IN � B A S E D T H E R AP IE S IN T YP E 2 D IA B E T E S 14 Buse JB, Rosenstock J, Sesti G, et al.
An increase in endocrine pancreatic mass, exocrine duct cell proliferation, and dysplasia were described in the organs of people with a history of treatment with incretin-based therapies when compared to those who had not had incretin-based treatment . The authors also suggested an increased risk for the evolution of neuroendocrine tumors . However, following an investigation by the European Medicines Agency (EMA) and a hearing by the US Food and Drugs Administration (FDA), as well as several other publications, concerns have been raised about the methodology and sample size of the study.
2012;1-7. Takeda J, Seino Y, Tanaka K, et al. Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor. Proc Natl Acad Sci U S A. 1987;84:7005-7008. Ugleholdt R, Poulsen ML, Holst PJ, et al. Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor. J Biol Chem. 2006;281:11050-11057. Volz A, Goke R, Lankat Buttgereit B, Fehmann HC, Bode HP, Goke B. Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma.
Handbook of Incretin-based Therapies in Type 2 Diabetes by Stephen Gough