By Toni Brown, Herman Holt Jr., Moses Lee (auth.), Moses Lee (eds.)
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"Heterocyclic antitumor antibiotics symbolize a vast type of ordinary items which are of common curiosity … . hence, a well-written, updated account of growth within the research of such compounds is predicted to be good acquired. … this monograph definitely has adequate medical worth to advantage inclusion in so much educational libraries and in business laboratories thinking about antibacterial and anticancer agent discovery. person researchers, nevertheless, may perhaps first desire to weigh the level to which this far-ranging selection of stories bargains sufficiently with themes of particular curiosity to their examine teams earlier than buying a private copy." (Gary I. Dmitrienko, magazine of the yank Chemical Society, Vol. 129, 2007)
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Content material: bankruptcy 1 necessities of Coordination Chemistry (pages 1–12): bankruptcy 2 ? ?Pyridine Coordination Compounds with Nontransition Metals (pages 13–185): bankruptcy three ? ?Pyridine Coordination Compounds with Transition Metals (pages 186–2067): bankruptcy four Coordination Compounds of Metals With Pyridine 1?
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Although this example is a curcumin analog and not a chalcone derivative, it has been included as this class of compounds exhibited anti-oxidant and COX-1/COX-2 activity. Scheme 45 shows a general reaction of the pyrazole chemistry reported by Pinto et al. . , 173) using similar reaction conditions as stated in Schemes 43 and 44. , 175) . Scheme 46 gives a general illustration of this reaction. Scheme 44 a Hydrazine hydrate, acetic acid  Scheme 45 a Hydrazine hydrate, MeOH, reﬂux, 24 h  Scheme 46 a Hydrazine hydrate or phenyl hydrazine, EtOH, reﬂux  Synthesis of Stilbene and Chalcone Analogs of Combretastatin 43 A different method of generating pyrazoles was reported by Aggarwal et al.
Yue and Larock also report the synthesis of these compounds using similar chemistry . Scheme 24 a HBF4 , NaNO2 , H2 O; b KSC(C)OEt, DMF; c MeOH, KOH d aq. 2 Methoxybenzofuran Compounds These compounds contain a furan ring fused to a benzene moiety in the 2,3-position. This synthesis was also described by Flynn et al.  and is shown in Scheme 25 involved the coupling of 2-iodo-5-methoxyphenol 104, 4-methoxyphenylethyne 105 to form the intermediate o-alkynylphenolate 106. Aryl iodide 107 was added to the phenolate in DMSO with heat.
2 Pyridine Compounds The synthesis and biological activity of these pyridine-containing compounds, in which the nitrogen points toward the B-ring, was described by Simoni et al. . A double Suzuki cross-coupling strategy was employed as previously described by the same group , and the synthesis is shown in Scheme 33. The desired diphenyl compound 129 was obtained in good yields from a Suzuki coupling in toluene; tetrakis(triphenylphosphine)palladium(0) was employed as the catalyst for the reaction, and Na2 CO3 provided the basic environment.
Heterocyclic Antitumor Antibiotics by Toni Brown, Herman Holt Jr., Moses Lee (auth.), Moses Lee (eds.)