By Yuri B. Yurov, Svetlana G. Vorsanova, Ivan Y. Iourov
This identify will specialise in the research of human interphase chromosomes and its relation to overall healthiness and affliction. Orchestrated association and human genome functionality in interphase nuclei on the chromosomal point were again and again proven to play an important function in numerous simple organic methods focused on consciousness and inheritance of genetic details inside of and among species. present biomedical sciences of post-genomic period refocus uncomplicated and utilized reviews of interphase nuclei genetics and genomics with distinctive consciousness to interphase chromosome habit in health and wellbeing and disease. also, comparable tactics are a aim of reviews elucidating the function of interphase chromosome habit in the course of improvement, chromosome/DNA replication, DNA reparation and so on. stories of interphase nuclei have an considerable impression on varied parts of biomedical sciences resembling telephone biology, neurobiology, melanoma learn, developmental biology, epigenetics, cytogenetics, and scientific genetics, as a complete. in addition, improvement of leading edge and emergent applied sciences to research interphase nuclei are heavily linked to software of those concepts in scientific, diagnostic and examine perform to resolve reproductive difficulties (including infertility and spontaneous abortions), to enquire congenital malformations (including these produced by means of aneuploidy and different chromosome abnormalities); genetic illnesses (including cardiac, immune, neurological and psychiatric diseases), and cancer. This identify will function a resource of latest helpful info and promising principles for a large viewers of execs in biomedicine together with researchers, scientists, and healthcare pros in human genetics, cytogenetics, and developmental biology.
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Extra info for Human Interphase Chromosomes: Biomedical Aspects
A study by Osborne et al. (2007) found that upon activation both genes are recruited to the same transcription factories, increasing their physical proximity. As proximity has been shown to be a key factor in translocations, this increases our understanding of why the t(12;15) is observed so frequently. In support of this realization, it was observed that c-Myc colocalized and transcribed with IgH at the expected frequency to give rise to the observed level of translocations (Osborne et al. 2007).
Genome Biol 5:R44 Peric-Hupkes D, Meuleman W, Pagie L, Bruggeman SW, Solovei I, Brugman W, Graf S, Flicek P, Kerkhoven RM, van Lohuizen M, Reinders M, Wessels L, van Steensel B (2010) Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation. Mol Cell 38:603–613 Rodríguez S, Eriksson M (2010) Evidence for the involvement of lamins in aging. Curr Aging Sci 3:81–89 Roix JJ, McQueen PG, Munson PJ, Parada LA, Misteli T (2003) Spatial proximity of translocationprone gene loci in human lymphomas.
It is assumed that the presence of additional genetic material corresponds to increased expression levels of the overrepresented sequences. This assumption is supported by a study on highly hyperdiploid pediatric ALL, showing that the presence of additional chromosomal material corresponded to an increased expression of the amplified loci (Gruszka-Westwood et al. 2004). Very few studies have addressed the issue of chromosome organization in cases of aneuploidy. Croft et al. (1999) did not see any repositioning of an extra chromosome 18 in Edward syndrome cells with a trisomy 18 (Croft et al.
Human Interphase Chromosomes: Biomedical Aspects by Yuri B. Yurov, Svetlana G. Vorsanova, Ivan Y. Iourov