By Icon Health Publications, Health Publica Icon Health Publications
This can be a 3-in-1 reference publication. It supplies a whole clinical dictionary overlaying countless numbers of phrases and expressions when it comes to hypothermia. It additionally provides huge lists of bibliographic citations. eventually, it presents info to clients on the way to replace their wisdom utilizing quite a few web assets. The booklet is designed for physicians, clinical scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to get to grips with learn devoted to hypothermia. in the event that your time is effective, this booklet is for you. First, you won't waste time looking out the web whereas lacking loads of suitable info. moment, the publication additionally saves you time indexing and defining entries. eventually, you won't waste time and cash printing countless numbers of web content.
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Additional info for Hypothermia - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
In our canine survival model of HCA, replicating clinical experience during cardiac operations, dogs subjected to 2 hours of circulatory arrest at 18degreesC sustain a consistent neurologic deficit and histologic pattern of selective neuronal death. We originally showed that administration of selective glutamate receptor antagonists before and after HCA-induced injury reduced the neuronal necrosis. We have now shown that neuronal death can occur by apoptotic or necrotic mechanisms. We showed that glutamate release after HCA results in accumulation of nitric oxide (NO), which mediates neuronal death and that inhibition of neuronal nitric oxide synthase (NOS) reduces production of NO in the brain and prevents apoptosis.
Indeed previous experiments using the BAL have shown that up to a 24-hour period of cold storage is feasible. However, longer storage time as well as improved viability and function is vital for its successful widespread application. Examination of the cellular mechanisms, specifically the gene expression patterns associated with the early phases of hypothermic damage, need to be examined in order to discover and subsequently test "protective" factors. New techniques in tissue culture and molecular/cellular biology make this goal attainable.
Duration of time to successfully enroll patients from this cohort of 15 children's hospitals for a future RCT will be estimated. This application will also result in creation of multiple documents needed to perform a RCT of hypothermia after cardiac arrest in childhood including study related data forms, study protocols, manuals of operation, institutional review board and informed consent related documents, and other materials. The PECARN will support all phases of this application with its existing clinical trials research infrastructure that includes a steering committee, five clinical trials supporting subcommittees, and a central data management coordinating center (CDMCC).
Hypothermia - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications, Health Publica Icon Health Publications