By Attilio Orazi
This booklet presents a hugely illustrated and accomplished account of the ailments of the human bone marrow. it is going to support skilled clinicians and people in education to reply to the sensible diagnostic questions that come up through the regimen research of bone marrow center biopsy specimens. during the textual content, histologic interpretation is built-in with scientific and laboratory findings. Emphasis is put on the assessment of peripheral blood, aspirate smear, clot part and center biopsy, in addition to ancillary options together with circulation cytometry and immunohistochemistry within the prognosis of hematologic issues of the marrow. The textual content is illustrated with a variety of colour figures, charts and tables, and outlines of actual case events utilizing the main up to date class platforms. Illustrated Pathology of Bone Marrow might be learn via all pathologists, hematologists and laboratory technicians thinking about the research of bone marrow specimens.
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Additional info for Illustrated Pathology of the Bone Marrow
Causes of various types of aplastic anemia (AA). 2. Grading of severity of aplastic anemia. , 1997). In most cases of aplastic anemia, the number of CD34-positive cells appears decreased to less than one-third of the normal frequency. 1. (A) Aspirate smear of aplastic anemia and (B) core biopsy. , macrophages) and lymphocytes. cells should raise concern for myelodysplasia. 3. 3. Diagnostic features observed in bone marrow biopsies in patients with aplastic anemia, hypoplastic myelodysplastic syndrome, or hypoplastic acute myeloid leukemia.
B-cell lymphocytosis is less common than T-cell lymphocytosis. , 1999). The patients have a persistent lymphocytosis, usually between 4 × 109 /L and 14 × 109 /L, with binucleated peripheral blood lymphocytes (Fig. 7). 7. (A) Peripheral blood smear showing lymphocytosis characterized by “abnormal” lymphocytes, including cleaved forms, in this case of B. pertussis infection. (B) A peripheral blood smear, illustrating findings seen in so-called benign binucleated lymphocytosis, a condition associated with persistent polyclonal B-cell lymphocytosis mostly seen in women who smoke.
American Journal of Surgical Pathology, 22, 1386–92. Elghetany, M. T. (1997). True histiocytic lymphoma: is it an entity? Leukemia, 11, 762–4. Favara, B. , Feller, A. , et al. (1997). Contemporary classification of histiocytic disorders. Medical and Pediatric Oncology, 29, 157–66. Florena, A. , & Campesi G. (1996). Immunophenotypical comparison of Gaucher’s and pseudo-Gaucher cells. Pathology International, 46, 155–60. Foucar, K. (2001). Miscellaneous disorders of the bone marrow, including stromal and bone abnormalities.
Illustrated Pathology of the Bone Marrow by Attilio Orazi