By Sudhesh Kumar, Stephen O'Rahilly
Diabetes is now one of many significant factors of morbidity around the world. in lots of circumstances, the onset of diabetes is innovative, constructing through a of insulin resistance. This e-book considers the improvement of this situation, its results and medical and healing aspects.
The e-book reports the traditional biology of insulin motion on glucose, lipids and proteins. It considers the pathological foundation for insulin resistance in animal types and people, and discusses the impression of heredity, nutritional components and workout. medical outcomes together with dyslipidaemia, high blood pressure and polycystic ovary syndrome, and healing suggestions for therapy also are examined.
* offers knowledgeable evaluate of the phenomenon of insulin resistance
* Brings jointly a bunch of contemporary examine for the 1st time
* Written by means of prime specialists in organic and scientific researchContent:
Chapter 1 The Insulin Receptor and Downstream Signalling (pages 1–62): Ken Siddle
Chapter 2 Insulin?Mediated legislation of Glucose Metabolism (pages 63–85): Daniel Konrad, Assaf Rudich and Amira Klip
Chapter three Insulin motion on Lipid Metabolism (pages 87–103): Keith N. Frayn and Fredrik Karpe
Chapter four The impact of Insulin on Protein Metabolism (pages 105–132): Laura J. S. Greenlund and okay. Sreekumaran Nair
Chapter five Genetically transformed Mouse versions of Insulin Resistance (pages 133–153): Gema Medina?Gomez, Christopher Lelliott and Antonio J. Vidal?Puig
Chapter 6 Insulin Resistance in Glucose Disposal and construction in guy with particular connection with Metabolic Syndrome and sort 2 Diabetes (pages 155–178): Henning Beck?Nielsen, Frank Alford and Ole Hother?Nielsen
Chapter 7 relevant law of Peripheral Glucose Metabolism (pages 179–206): Stanley M. Hileman and Christian Bjorb?k
Chapter eight dating among fats Distribution and Insulin Resistance (pages 207–235): Philip G. McTernan, Aresh Anwar and Sudhesh Kumar
Chapter nine PPAR? and Glucose Homeostasis (pages 237–267): Robert okay. Semple and Stephen O'Rahilly
Chapter 10 Adipokines and Insulin Resistance (pages 269–295): Daniel okay. Clarke and Vidya Mohamed?Ali
Chapter eleven nutritional elements and Insulin Resistance (pages 297–316): Jeremy Krebs and Susan Jebb
Chapter 12 actual task and Insulin Resistance (pages 317–400): Nicholas J. Wareham, Soren Brage, Paul W. Franks and Rebecca A. Abbott
Chapter thirteen Genetics of the Metabolic Syndrome (pages 401–450): George Argyropoulos, Steven Smith and Claude Bouchard
Chapter 14 Insulin Resistance and Dyslipidaemia (pages 451–466): Benoit Lamarche and Jean?Francois Mauger
Chapter 15 Insulin Resistance, high blood pressure and Endothelial disorder (pages 467–483): Stephen J. Cleland and John M. C. Connell
Chapter sixteen Insulin Resistance and Polycystic Ovary Syndrome (pages 485–509): Neus Potau
Chapter 17 Syndromes of serious Insulin Resistance (SSIRs) (pages 511–533): David Savage and Stephen O'Rahilly
Chapter 18 healing concepts for Insulin Resistance (pages 535–560): Harpal S. Randeva, Margaret Clarke and Sudhesh Kumar
Chapter 19 Drug treatment for Insulin Resistance – a glance on the destiny (pages 561–585): Bei B. Zhang and David E. Moller
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Extra resources for Insulin Resistance: Insulin Action and Its Disturbances in Disease
15. De Meyts, P. and Whittaker, J. (2002) Structural biology of insulin and IGF1 receptors: implications for drug design. Nature Rev Drug Discov 1, 769–783. 16. Adams, T. , Epa, V. , Garrett, T. P. J. and Ward, C. W. (2000) Structure and function of the type 1 insulin-like growth factor receptor. Cell Mol Life Sci 57, 1050–1093. 17. Yip, C. C. and Ottensmeyer, P. (2003) Three-dimensional structural interactions of insulin and its receptor. J Biol Chem 278, 27 329–27 332. 18. Hubbard, S. R. and Till, J.
Seino, M. and Bell, G. I. (1990) Human insulin receptor gene. Diabetes 39, 129–133. 15. De Meyts, P. and Whittaker, J. (2002) Structural biology of insulin and IGF1 receptors: implications for drug design. Nature Rev Drug Discov 1, 769–783. 16. Adams, T. , Epa, V. , Garrett, T. P. J. and Ward, C. W. (2000) Structure and function of the type 1 insulin-like growth factor receptor. Cell Mol Life Sci 57, 1050–1093. 17. Yip, C. C. and Ottensmeyer, P. (2003) Three-dimensional structural interactions of insulin and its receptor.
Two further members of the IRS family have been identified, which show sequence similarity to IRS-1 and -2 but more restricted distribution. 164 It was identified initially in an embryonic kidney cell line and has a very restricted distribution in vivo, being expressed predominantly in brain and thymus. 165 IRS-1 and 2 contain a very large number of potential sites of serine phosphorylation, as defined by scanning for consensus sequences that could be substrates for known kinases. A multitude of kinases phosphorylate these IRSs in vitro and/or in intact cells, including conventional, atypical and novel PKCs, PKB/Akt, ERK/MAPK, mTOR, JNK (c-Jun N-terminal kinase), IKKβ (inhibitor kappa B kinase), AMPK (AMP-dependent protein kinase), PI 3kinase, casein kinase II and GSK3 (glycogen synthase kinase-3) (reviewed in references 166–169).
Insulin Resistance: Insulin Action and Its Disturbances in Disease by Sudhesh Kumar, Stephen O'Rahilly