Integrated endocrinology by John Laycock, Karim Meeran PDF

By John Laycock, Karim Meeran

ISBN-10: 0470688122

ISBN-13: 9780470688120

ISBN-10: 0470688130

ISBN-13: 9780470688137

ISBN-10: 1118450639

ISBN-13: 9781118450635

ISBN-10: 1118450647

ISBN-13: 9781118450642

This cutting edge textbook presents a readable, modern and entirely built-in advent to endocrine glands, their hormones and the way their functionality pertains to homeostasis. It explores the pathology of endocrine sickness via touching on the underpinning technology via a wealth of scientific situations and examples. The e-book integrates uncomplicated and scientific points for a variety of endocrine glands and their hormones and Read more...


This leading edge textbook presents a readable, modern and completely built-in creation to endocrine glands, their hormones and the way their functionality pertains to homeostasis. It explores the Read more...

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A typical receptor of this type would be a transmembrane protein having an extracellular domain to which the hormone molecule can attach, a 26 Chapter 1 section of the receptor spanning the membrane and finally an intracellular domain which would be associated with a specific transduction process. One large, ubiquitous family of such receptors is the seven-transmembrane receptor group, so named because all the receptors in this group have seven membrane-spanning helices connecting the extracellular and intracellular domains.

Hydrolysis of the GTP bound to β-tubulin destabilises the microtubule allowing it to depolymerise, which accounts for the dynamic nature of its structure. Microtubules have various functions within the cell, including an involvement in regulating the movement of vesicles from within the cytoplasm towards the plasma membrane. The movement of vesicles from the Golgi complex to the outer plasma membrane is sometimes called vesicle ‘trafficking’. 9). Various other molecules, such as recognition and anchoring proteins, play an important role in the intracellular transport process of vesicles.

For a more detailed discussion of ovulation, see Chapter 7. Internal feedback In addition to the control loops linking ‘effect’ to hormone via the general circulation, there is considerable regulation within the cells of an endocrine gland. We have already seen how the endocrine cell itself acts as an integrator of probably many different signals arriving at that cell at any given moment. This implies considerable intracellular regulation at various levels, including synthesis, storage, removal or release of the hormone.

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Integrated endocrinology by John Laycock, Karim Meeran

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