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Extra resources for Interdisciplinary Reviews - Nanomedicine and Nanobiotechnology
J Magn Magn Mater 1993, 122:383–386. 29. von zur Muhlen C, von Elverfeldt D, Bassler N, Neudorfer I, Steitz B, et al. Superparamagnetic iron oxide binding and uptake as imaged by magnetic resonance is mediated by the integrin receptor Mac-1 (CD11b/CD18): implications on imaging of atherosclerotic plaques. Atherosclerosis 2007, 193(1):102–111. 17. Wilhelm C, Billotey C, Roger J, Pons JN, Bacri JC, et al. Intracellular uptake of anionic superparamagnetic nanoparticles as a function of their surface coating.
Dousset V, Ballarino L, Delalande C, Coussemacq M, Canioni P, et al. Comparison of ultrasmall particles of iron oxide (USPIO) T2-weighted, conventional T2-weighted and gadolinium-enhanced T1-weighted MR images in rats with experimental autoimmune encephalomyelitis. Am J Neuroradiol 1999, 20(2):223–227. 111. Engberink RD, Blezer EL, Hoff EI, van der Pol SM, van der Toorn A, et al. MRI of monocyte infiltration in an animal model of neuroinflammation using SPIOlabeled monocytes or free USPIO. J Cereb Blood Flow Metab 2008, 28(4):841–851.
SPIO had been administered 24 h before each measurement. The arrows highlight the signal attenuation in areas corresponding to synovial fluid effusion. (b) Coronal slice through the knee of a vehicle-treated rat, 16 days after antigen administration. Berlin-blue-Giemsa-stained histological images from the same knee. Arrows indicate a massive presence of iron-loaded macrophages. (c) Course of MRI signal intensities (mean ± sem, N = 5 for each group of knees) relative to prechallenge values. Control knees refer to contralateral, vehicle-treated knees, from the same rats that had received antigen on the ipsilateral joints.
Interdisciplinary Reviews - Nanomedicine and Nanobiotechnology