By S. Arora
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Additional resources for Iron Metabolism
ALAS2 (erythroid-specific 5-aminolevulinic acid synthase) mRNA encodes for the first and rate-limiting enzyme in the haem biosynthesis pathway. , 1991). , 2005). Grx5 protein is required for iron-sulphur cluster assembly and its abrogation shifts IRP1 conformation to an IRE-binding protein that leads to Alas2 repression and cytosolic iron depletion that also activates IRP2, which will further contribute to the repression of Alas2. , 2007). Surprisingly, in this patient the anaemia was worsened by blood transfusions but partially reversed by iron chelation, presumably because iron chelation will redistribute iron to the cytosol, which might decrease IRP2 excess, improving haem 42 Iron Metabolism synthesis and anaemia.
The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation. Endocrinology 2007; 148: 2663–8.  Bekri S, Gaul P, Anty R, et al. Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterologia 2006; 131: 788– 96.  Dallalio G, Law E, Means Jr RT. Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations. Blood 2006;107:2702–4.  Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard S, Devaux I, et al.
No crystal structure of IRP2 is available as of yet, and forthcoming experiments will allow us to elucidate the role (if any) of the extra amino acid residues in IRP2 IRE binding specificity and/or their role in protein degradation. Ultimately, the crystallization of IRP2, especially in a complex with IRE, will be necessary to precisely map the RNA–protein interactions and further shed light on its mechanistic properties (Wang & Pantopoulos, 2011). 2 Regulation of IRPs by other stimuli than iron Iron was the first identified regulator of the IRP/IRE network however various other stimuli, drugs and pathological agents have been reported to affect IRP activity.
Iron Metabolism by S. Arora