Download e-book for kindle: Molecular and Cellular Endocrinology by E. Edward Bittar and Neville Bittar (Eds.)

By E. Edward Bittar and Neville Bittar (Eds.)

ISBN-10: 1559388153

ISBN-13: 9781559388153

This quantity seeks to supply a coherent account of the technological know-how of molecular and mobile endocrinology. It covers components comparable to endocrine suggestions keep watch over in wellbeing and fitness and ailment, insulin resistance and insulin deficiency, the endothelins, and genetic engineering within the research of hormones.

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Res. 14, 289. , & Guillemin, R. (1967). Competition between thyroxine and TRF at the pituitary level in the release of TSH. Proc. Roy. Soc. Exp. Biol. Med. 125,210. Chapter 2 Mechanisms of Negative and Positive Feedback of Steroids in the Hypothalamic-Pituitary System GEORGE FINK Introduction Negative Feedback in the Hypothalamic-Pituitary-Adrenal Axis Introduction Principles of Negative Feedback Illustrated by the HPA System Clinical Manifestations of Disordered Glucocorticoid Feedback Regulation Summary Negative Feedback in the Hypothalamic-Pituitary-Gonadal Axis Introduction Summary Steroid Positive Feedback: Spontaneous Gonadotropin and Prolactin Surges General Overview of the Mechanism of the Spontaneous Gonadotropin Surge Generation of the LHRH Surge Changes in Pituitary Responsiveness to LH-Releasing Hormone The Apparent Paradox of Negative-Positive Feedback of Estradiol- 1713and Progesterone Principles of Medical Biology, Volume 10A Molecular and Cellular Endocrinology, pages 29-100.

The Relationship between TSH and TRH The distribution of T4 in a healthy population is symmetrical (Figure 3b). When the clinically observed distribution of T4 is simulated by varying the demand level of TRH, using the mathematical relationships established earlier, the corresponding 60- 50 40 No$. 30 20 10 0 6( 70 80 90 100 110 120 130 140 FT 4 index nmol/I Figure 3b. The frequency distribution of FT4 index in 188 normal adults. 150 Control Loop Theory 13 distribution of TSH is skewed to the left (Figure 4).

O , . , . o...... ~176 .... ~176176176 .... ~176176176 0 ,o, 60 70 .... ,, . . . 80 , . . . . . . . . . , . . . . . . ~,0 nmol/1 Figure 6. A family of constant TRH curves obtained by calculation. Their points of intersection with the abscissa represent perfect control (T4 - TRH, 0 error, TSH = 0). Positions further up the curves represent falling thyroid efficiency at constant level of TRH demand. The gradient of the curves (pituitary gain) determines the degree of departure of T4 from optimum for any given reduction in thyroid gain, and the corresponding TSH level.

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Molecular and Cellular Endocrinology by E. Edward Bittar and Neville Bittar (Eds.)


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