Download PDF by Ernest Schoffeniels: Molecular Aspects of Bioelectricity

By Ernest Schoffeniels

ISBN-10: 0080263712

ISBN-13: 9780080263717

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Since Ca selectively inhibits the Na -flow there appea rs competition for sites and thus transient, short-lived binding of N a and Ca ions in the Na pathway (Takeuchi, A. , 1972; see also Gage and van Helden, 1979) . 34 E. Neumann 2+ The detailed role of Ca ions in a c t i v a t i o n and i n a c t i v a t i o n is not yet m o l e c u l a r l y u n d e r s t o o d . In frog muscle increased external Ca c o n c e n t r a t i o n slightly d e c r e a s e s mepc decay time c o n s t a n t s and life t i m e s of open c h a n n e l s (see Table 3 of M a g l e b y and W e i n s t o c k , 1 9 8 0 ) .

And K a r l i n , A. ( 1 9 7 8 ) . B i o c h e m . B i o p h y s . Res. , 84, 845-851. , and K a t z , B. ( 1 9 5 7 ) . P r o c . R o y . S o c . L o n d . , Ser. B 146, 369-81. M. and M c N a m e e , M . G . ( 1 9 8 0 ) . B i o c h e m i s t r y , 1 9 , 8 9 0 - 9 5 . D e M o t t a , G . E . , and del G a s t i l l o , J. ( 1 9 7 7 ) . N a t u r e , 2 7 0 , 1 7 8 - 1 8 0 . , and N e u m a n n , E . ( 1 9 8 0 ) . P r o c . N a t l . A c a d . U S A , 7 7 , in p r e s s . , and N e u m a n n , E .

5) when the term C*I_ is not c o n s i d e r e d . In a r e c e n t g , , _ _ " _ _ E study of the I -dependence of k „ and of the c o r r e s p o n d i n g e q u i l i b r i u m smpirical value C = 0 . 5 M led to Z = -7 as a meaning the e m p i r i c a l value C = 0 . 5 M led to Z = -7 as a m e a n i n g f u l estimate (Nolte and N e u m a n n , 1 9 8 0 , in p r e p . ) Thus at least seven estimate (Nolte and N e u m a n n , 1 9 8 0 , in p r e p . ) Thus at least sever m o n o v a l e n t anionic g r o u p s c o n t r i b u t e to the c o m p a r a t i v e l y large v a l u e s m o n o v a l e n t anionic g r o u p s c o n t r i b u t e to the c o m p a r a t i v e l y large Λ Lok 1 0 for b o t h the n o n - s u b s t r a t e N - m e t h y l a c r i d i n i u m and acetylthiorface l iU M s ) , suggesting that an enzyme surfe choline ( k 1 9 = 0 .

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Molecular Aspects of Bioelectricity by Ernest Schoffeniels


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