Get Neurodegenerative Diseases: Clinical Aspects, Molecular PDF

By Daniela Galimberti, Elio Scarpini

ISBN-10: 1447163796

ISBN-13: 9781447163794

ISBN-10: 144716380X

ISBN-13: 9781447163800

This booklet offers an summary of the present wisdom at the commonest neurodegenerative illnesses, together with Alzheimer’s sickness, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and extra neurodegenerative illnesses. diverse facets of every sickness are reviewed, together with medical matters, remedies, easy discoveries (genetics and molecular biology), and translation of easy examine into biomarkers for early prognosis. moreover, rising info point out that neurodegeneration turns out to even be found in classically non-degenerative problems. hence, a bankruptcy approximately overlapping mechanisms among dementias and psychiatric issues is integrated, in addition to an outline of the function of neurodegeneration in a number of sclerosis.

Neurodegenerative Diseases is geared toward clinicians, quite these operating in educational hospitals. This multidisciplinary e-book can be of curiosity to uncomplicated researchers in clinical fields.

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Extra resources for Neurodegenerative Diseases: Clinical Aspects, Molecular Genetics and Biomarkers

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In the cytoplasm, mature miRNAs associate with other proteins to form the RNA-induced silencing complex (RISC), enabling the miRNA to imperfectly pair with cognate miRNA transcripts. The target mRNA is then degraded by the RISC, preventing its translation into protein [49, 50]. miRNAmediated repression of translation is involved in many cellular processes, such as differentiation, proliferation, and apoptosis, as well as other key cellular mechanisms [51, 52]. Although the origin of some neurological diseases is still not well understood, it is increasingly acknowledged that epigenetics may contribute significantly to the diagnostics of these pathologies.

In the late stages of the disease, apraxia affects every task of daily life, making impossible even the simplest action, such as taking a shower. Dyscalculia causes troubles with money, in particular, cash. Patients cannot distinguish between 50 and 500; in this phase they often lose money and are victims of cheaters. Prosopagnosia completes the clinical picture at the late stages of the disease. The patient is unable to recognize his friends or relatives’ faces, making coping with their disease even more difficult.

2008;451:147–52. 58. Ma L, Teruya-Feldstein J, Weinberg RA. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 2007;449:682–8. 59. Png KJ, Yoshida M, Zhang XH, Shu W, Lee H, Rimner A, et al. MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer. Genes Dev. 2011;25:226–31. 60. Song G, Zhang Y, Wang L. MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation.

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Neurodegenerative Diseases: Clinical Aspects, Molecular Genetics and Biomarkers by Daniela Galimberti, Elio Scarpini


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