Neurotoxicology: Approaches and Methods - download pdf or read online

By Louis W. Chang, William Slikker Jr.

ISBN-10: 0080537472

ISBN-13: 9780080537474

ISBN-10: 012168055X

ISBN-13: 9780121680558

Neurotoxicology: techniques and techniques presents a special and accomplished presentation of the present ideas and cutting-edge equipment for the evaluation of neurotoxicity. The publication analyzes quite a few thoughts to be had and discusses their strengths and weaknesses. This quantity will function a great table significant other and laboratory consultant for all investigators, researchers, clinicians, and scholars drawn to neurotoxicology. The the world over knowngroup of editors divide the publication into seven sections: Neuromorphological and Neuropathological methods; Neurophysiological ways; Neurobehavioral Toxicology; Neurochemical and Biomolecular methods; In-Vitro types; scientific Neurotoxicology; and possibility overview of Neurotoxicity . every one part yields the main updated details by means of specialists of their fields. Meticulously geared up and edited, Neurotoxicology: methods and techniques is the main authoritative and well-planned neurotoxicology booklet out there. Key positive factors * Discusses neurobehavioral checking out equipment for evaluate of neural dysfunctions * Explains state of the art diagnostic tools, similar to clinico-neuropsychological and neurophysiological equipment, for sufferers faced via neurotoxic difficulties * Discusses In Vitro tools, together with aggregating mind mobilephone equipment, organotypic cultures, and using human neuronal cellphone strains for the evaluation of neurotoxicity * provides step by step systems for plenty of tools * presents cutting-edge neuromorphological and biomolecular equipment and ways for neurotoxicity research

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Extra resources for Neurotoxicology: Approaches and Methods

Example text

1992). Basic histopathological alternatives in the central and peripheral nervous systems: classification, identification, approaches, and techniques. In Neurotoxicology (M. B. ), pp. 223-252, CRC Press, Boca Raton, Florida. Chang, L. W. (1994). Introduction to basic principles of neurocytology and general concepts on neurotoxicopathology. In Principles ofNeurotoxicology (L. W. ), pp. 3-34, Dekker, New York. Chang, L. W. (1995). Neurotoxicology of organotins and organoleads. In Handbook ofNeurotoxicology (L.

19). I. Holzer's Method f o r Astrocytic Fiber Although fibroblasts react to injuries and scarring in tissues of peripheral organs, astrocytes enlarge and As in any chemical reaction, histopathological and histochemical staining techniques are subjected to both false positive and false negative results. To guard against these occurrences, proper "controls" should be used. These controls include: (1) positive control, a tissue sample known to lead to a positive staining result; (2) negative control, a tissue sample known to lack the tissue component in question, which therefore will certainly give a negative staining result; and (3) normal control, tissue samples obtained from a normal animal (same species, sex, and age as the test animals) 1 Neurotoxicity A s s e s s m e n t 17 FIGURE 17 Rat sciatic nerve: normal, paraffin-embedded, longitudinal section, Bielschowsky's stain.

Spencer and H. H. ), pp. 296-308, Williams & Wilkins, Baltimore/London. United States Office of Technology Assessment (1990). Neurotoxicity: identifying and controlling poisons of the nervous system. S. C. CHAPTER 2 Neuroanatomical Techniques for Labeling Neurons and Their Utility in Neurotoxicology K A R L F. S. Environmental Protection Agency Research Triangle Park, North Carolina 27711 terations that can only be assessed with morphological approaches. This chapter describes neuroanatomical methods that are particularly well suited for the characterization of such structural alterations.

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Neurotoxicology: Approaches and Methods by Louis W. Chang, William Slikker Jr.


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