By Harald H. Sitte, Michael Freissmuth
This ebook is a consultant survey of the present prestige of the constitution, functionality, legislation and molecular pharmacology of Neurotransmitter Transporters. It presents an outline of insights generated some time past 5 years. the amount serves as an invaluable compendium of present ideas and an inspiring place to begin. it's a resource for college students attracted to this rising box in addition to for knowledgeable scientists searching for an replace.
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This e-book is a consultant survey of the present prestige of the constitution, functionality, law and molecular pharmacology of Neurotransmitter Transporters. It offers an summary of insights generated some time past 5 years. the amount serves as an invaluable compendium of present innovations and an inspiring start line.
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Extra info for Neurotransmitter Transporters (Handbook of Experimental Pharmacology) (Volume 175)
52 2 . . . . . . . Abstract Cotransporters use energy stored in Na+ or H+ gradients to transport neurotransmitters or other substrates against their own gradient. Cotransport is rapid and efﬁcient, and at synapses it helps terminate signaling. Cotransport in norepinephrine (NET), epinephrine (EpiT), dopamine (DAT), and serotonin (SERT) transporters couples downhill Na+ ﬂux to uphill transmitter ﬂux. NETs, for example, attenuate signaling at adrenergic synapses by efﬁciently clearing NE from the synaptic cleft, thus preparing the synapse for the next signal.
The decay is a measure of the ﬂuorescence lifetime. Lifetime spectrometers and some microscopes utilize time-resolved ﬂuorescence lifetime measurements. FLIM has a few disadvantages. Currently, commercial FLIM systems are not readily available, and FLIM images have a slow acquisition rate. Several data points must be collected for each pixel in order to calculate the corresponding ﬂuorescence lifetime. Multiple data point acquisition signiﬁcantly delays image acquisition. A lifetime image can require as much as 6 min to obtain a single plane of an HEK-293 cell.
1985; Gratton et al. 1984; Jameson et al. 1984). Measuring a sample of known lifetime accounts for the microscope response, and all lifetime changes are additive. Alternatively, the ﬂuorescence lifetime can be established by measuring the ﬂuorescence Fig. 7 A,B Frequency domain lifetime measurements. hNET-293 cells are exposed to 2 µM ASP+ for 5 min prior to image acquisition. The changes in ﬂuorescence intensity (A) and ﬂuorescence lifetime (B) were examined using ﬂuorescence lifetime imaging microscopy (FLIM) (see Sect.
Neurotransmitter Transporters (Handbook of Experimental Pharmacology) (Volume 175) by Harald H. Sitte, Michael Freissmuth