Download e-book for kindle: Neurotransmitter Transporters (Handbook of Experimental by Harald H. Sitte, Michael Freissmuth

By Harald H. Sitte, Michael Freissmuth

ISBN-10: 3540297839

ISBN-13: 9783540297833

ISBN-10: 3540297847

ISBN-13: 9783540297840

This ebook is a consultant survey of the present prestige of the constitution, functionality, legislation and molecular pharmacology of Neurotransmitter Transporters. It presents an outline of insights generated some time past 5 years. the amount serves as an invaluable compendium of present ideas and an inspiring place to begin. it's a resource for college students attracted to this rising box in addition to for knowledgeable scientists searching for an replace.

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Read or Download Neurotransmitter Transporters (Handbook of Experimental Pharmacology) (Volume 175) PDF

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Neurotransmitter Transporters (Handbook of Experimental - download pdf or read online

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Extra info for Neurotransmitter Transporters (Handbook of Experimental Pharmacology) (Volume 175)

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52 2 . . . . . . . Abstract Cotransporters use energy stored in Na+ or H+ gradients to transport neurotransmitters or other substrates against their own gradient. Cotransport is rapid and efficient, and at synapses it helps terminate signaling. Cotransport in norepinephrine (NET), epinephrine (EpiT), dopamine (DAT), and serotonin (SERT) transporters couples downhill Na+ flux to uphill transmitter flux. NETs, for example, attenuate signaling at adrenergic synapses by efficiently clearing NE from the synaptic cleft, thus preparing the synapse for the next signal.

The decay is a measure of the fluorescence lifetime. Lifetime spectrometers and some microscopes utilize time-resolved fluorescence lifetime measurements. FLIM has a few disadvantages. Currently, commercial FLIM systems are not readily available, and FLIM images have a slow acquisition rate. Several data points must be collected for each pixel in order to calculate the corresponding fluorescence lifetime. Multiple data point acquisition significantly delays image acquisition. A lifetime image can require as much as 6 min to obtain a single plane of an HEK-293 cell.

1985; Gratton et al. 1984; Jameson et al. 1984). Measuring a sample of known lifetime accounts for the microscope response, and all lifetime changes are additive. Alternatively, the fluorescence lifetime can be established by measuring the fluorescence Fig. 7 A,B Frequency domain lifetime measurements. hNET-293 cells are exposed to 2 µM ASP+ for 5 min prior to image acquisition. The changes in fluorescence intensity (A) and fluorescence lifetime (B) were examined using fluorescence lifetime imaging microscopy (FLIM) (see Sect.

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Neurotransmitter Transporters (Handbook of Experimental Pharmacology) (Volume 175) by Harald H. Sitte, Michael Freissmuth


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