Read e-book online New Vaccine Technologies (Medical Intelligence Unit 26) PDF

By Ronald W. Ellis

ISBN-10: 0585408521

ISBN-13: 9780585408521

ISBN-10: 1587060507

ISBN-13: 9781587060502

The advance of recent vaccine applied sciences deals extra power for significantly lowering all over the world mortality and morbidity from infectious illnesses. This e-book systematically addresses all of the significant on hand direct and allowing applied sciences that have contributed to the revolutionized learn and improvement, therefore advancements to present vaccines. Its target market is either examine and improvement employees within the box, in addition to health-care group of workers who use vaccines. it's going to function a useful sourcebook within the vaccine box.

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Extra info for New Vaccine Technologies (Medical Intelligence Unit 26) (Biotechnology Intelligence Unit) 2001

Sample text

27 The fundamental assumption of such trials is that showing Clinical Issues for New Vaccine Technologies 27 noninferiority is evidence of efficacy. This especially applies to vaccines combining multiple antigens already available as separate vaccines and to the use of new technologies to improve the safety of the manufacturing process of already existing vaccines without increasing their efficacy. In this design, the choice of the control vaccine is critical. It has to be a well-accepted standard vaccine across different geographical regions and one for which efficacy has been satisfactorily and consistently proven.

As all these technological advances proceed, it is likely that the limiting factor in developing new vaccines for human use will continue to be a more comprehensive understanding of immunology. Some areas in which increased knowledge would have a practical payoff for vaccine development are the immunobiology of pathogens, the type and specificity of immune response required for persistent protection against disease, the attainment of mucosal immunity and the optimal vaccination strategy to achieve this protection.

52. Jansen KU, Rosolowsky M, Schultz LD et al. Vaccination with yeast-expressed cottontail rabbit papillomavirus (CRPV) virus-like particles protects rabbits from CRPV-induced papilloma formation. Vaccine 1995; 13:1509-1514. 53. Crawford SE, Labbe M, Cohen J et al. Characterization of virus-like particles produced by the expression of rotavirus capsid proteins in insect cells. J Virol 1994; 68:5945-5952. 54. Miyamura K, Kajigaya S, Momoeda M et al. Parvovirus particles as platforms for protein presentation.

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New Vaccine Technologies (Medical Intelligence Unit 26) (Biotechnology Intelligence Unit) 2001 by Ronald W. Ellis

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