Nucleosides, Nusleotides and their Biological Applications - download pdf or read online

By Rideout

ISBN-10: 0125879806

ISBN-13: 9780125879804

ISBN-10: 032314053X

ISBN-13: 9780323140539

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Rideout, J. , and Elion, G. , Carbohydr. Res. 97:139 (1981). 33. Huang, M . - C , Montgomery, J. , Thorpe, M. C , Stewart, E. , Secrist III, J. , and Blakley, R. , submitted. 34. Montgomery, J. , Clayton, S. , Thomas, H. , Shannon, W. , Bodner, A. , Cantoni, G. , and Chiang, P. 35. , J. Med. Chem. J. , (1982). J. Med. Chem. 10:665 36. Shealy, Y. , and Clayton, J. , J. Am. Chem. Soc. 91:3075 (1967). (1969). 37. Cerraak, R. , Tetrahedron Lett. 22:2331 (1981). 38. Chilson, 0. , 102:77 and Fisher, J.

The carbocyclic analogs of 3- and 7-deazaadenosine are also resistant to deamination and are cytotoxic, even though only the 7deaza compound appears to be phosphorylated. The 3-deaza compound has been found to be converted, to a small extent, to the analog of adenosylhomocysteine in a single cell line, and is a potent anti­ viral agent against vaccinia and several RNA viruses. ACKNOWLEDGMENTS I wish to acknowledge the contributions of Drs. L. L. , Dr. F. M. , and Dr. W. C. , and their staffs. I would also like to acknowledge our collaborations with Drs.

S47 Biochem. (1981). 78. Shealy, Y. , and Clayton, J. , J. Am. Chem. Soc. 91:3075 (1969). 79. , Montgomery, J. , Cantoni, G. , and Chiang, P. , Biochemistry. 80. , Pharmacol. L. , 20:110 (1981). Allan, P. , and Hill, D. , Mol. 4:208 (1968). 81. , personal communication. H. Burchenal Β· Leyland-Jones B. Watanabe R. Klein C. J. Fox Memorial Sloan-Kettering Cancer Center New York, New York 1 This work was supported the American Cancer Society Grant CH- 27W; National Cancer Institute Grants CA-05826, CA-08748, CA16534, CA-18601, CA-18856, and CA-27569; and the Hearst Found.

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