By Susumu Seino, Graeme I. Bell
The beta cells of the pancreatic islets of Langerhans are the one cells within the physique that produce and secrete insulin. This metabolic hormone performs a valuable function within the upkeep of glucose homeostasis, regulating glucose uptake in muscle and adipose tissue in addition to carbohydrate, fats, and protein metabolism in those tissues and the liver.
This booklet offers a entire up to date assessment of the beta cellphone in healthiness and disorder. Chapters tackle the structure and pathology of ordinary and diabetic pancreatic islets; law of beta-cell proliferation and loss of life; the opportunity of stem cells and extra-pancreatic tissues as beta-cell alternative cures; insulin biosynthesis; rules of insulin secretion together with metabolic keep an eye on, ion channels, hole junctions, cyclic AMP, incretins, and exocytosis; improvement of novel imaging recommendations; and genetic issues of the beta phone. a main target of the publication is to motivate scholars and younger uncomplicated and scientific investigators to develop into actively concerned about diabetes examine and the quest for brand new methods to avoid and deal with diabetes.
Read Online or Download Pancreatic Beta Cell in Health and Disease PDF
Best endocrinology & metabolism books
During the last few a long time, heart problems and diabetes have emerged as significant public illnesses, either as unique scientific entities and as comorbid stipulations. consequently, the fields of vascular biology and endocrinology are operating extra heavily now than ever prior to. With chapters through popular specialists, Cardiovascular Endocrinology: Shared Pathways and medical Crossroads emphasizes the enormous physiological interrelationships and scientific correlations among the specialties of cardiovascular drugs and endocrinology.
This e-book is predicated on shows given on the 5th foreign Symposium on dietary facets of Osteoporosis held in Lausanne, Switzerland in 2003. even supposing a regularly overlooked bankruptcy of scientific study, the dietary impacts on bone healthiness used to be a mentioned subject at this congress. additionally mentioned have been new insights into the position of proteins, supplements, potassium, greens, nutrients acid load, mineral waters and calcium.
This ebook has been created for sufferers who've determined to make schooling and learn an essential component of the remedy technique. even though it additionally provides info invaluable to medical professionals, caregivers and different health and wellbeing execs, it tells sufferers the place and the way to appear for info protecting almost all themes on the topic of a number of endocrine neoplasia sort 1 (also hyperparathyroidism; MEN1; Sipple's syndrome; Wermer's syndrome), from the necessities to the main complicated components of analysis.
Endocrine disruption represents probably the most debatable environmental problems with our time. Mounting proof stemming from greater than 10 years of experimental, epidemiological and medical experiences has remodeled the as soon as regularly discounted topic of endocrine disruptors into a subject of great problem not just in the medical neighborhood yet between society as a complete.
- Medications and Diabetes Risk: Mechanisms and Approach to Risk Reduction
- Physical activity and type 2 diabetes : therapeutic effects and mechanisms of action
- Staged Diabetes Management
- Practical Manual of Thyroid and Parathyroid Disease
Extra info for Pancreatic Beta Cell in Health and Disease
Genes Dev 11:1662–1673 Transcriptional Regulation of Insulin Gene Expression 25 27. Ahlgren U, Jonsson J, Edlund H (1996) The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deﬁcient mice. Development 122:1409–1416 28. Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai MJ (1997) Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deﬁcient mice. Genes Dev 11:2323–2334 29.
Gehring WJ, Affolter M, Burglin T (1994) Homeodomain proteins. Annu Rev Biochem 63:487–526 42. Trainor PA, Krumlauf R (2001) Hox genes, neural crest cells and branchial arch patterning. Curr Opin Cell Biol 13:698–705 43. Leonard J, Peers B, Johnson T, Ferreri K, Lee S, Montminy MR (1993) Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol Endocrinol 7:1275–1283 44. Miller CP, McGehee RE Jr, Habener JF (1994) IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene.
The connecting peptide does not prevent proinsulin from selfassociating to form dimers and zinc-stabilized hexamers [24,25]. The typical length of the C-peptide (30–35 amino acids (aa)) is necessary for efﬁcient processing of proinsulin by the prohormone convertases  and also may enhance its folding and intracellular transport. , intact proinsulin exhibits 3%–5% of the receptor binding and biologic activity of insulin in vitro [12,27]. Secreted proinsulin and/or intermediate forms do not undergo further cleavage in the circulation or in tissues .
Pancreatic Beta Cell in Health and Disease by Susumu Seino, Graeme I. Bell