Pancreatic Beta Cell in Health and Disease by Susumu Seino, Graeme I. Bell PDF

By Susumu Seino, Graeme I. Bell

ISBN-10: 4431754512

ISBN-13: 9784431754510

The beta cells of the pancreatic islets of Langerhans are the one cells within the physique that produce and secrete insulin. This metabolic hormone performs a valuable function within the upkeep of glucose homeostasis, regulating glucose uptake in muscle and adipose tissue in addition to carbohydrate, fats, and protein metabolism in those tissues and the liver.

This booklet offers a entire up to date assessment of the beta cellphone in healthiness and disorder. Chapters tackle the structure and pathology of ordinary and diabetic pancreatic islets; law of beta-cell proliferation and loss of life; the opportunity of stem cells and extra-pancreatic tissues as beta-cell alternative cures; insulin biosynthesis; rules of insulin secretion together with metabolic keep an eye on, ion channels, hole junctions, cyclic AMP, incretins, and exocytosis; improvement of novel imaging recommendations; and genetic issues of the beta phone. a main target of the publication is to motivate scholars and younger uncomplicated and scientific investigators to develop into actively concerned about diabetes examine and the quest for brand new methods to avoid and deal with diabetes.

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Genes Dev 11:1662–1673 Transcriptional Regulation of Insulin Gene Expression 25 27. Ahlgren U, Jonsson J, Edlund H (1996) The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 122:1409–1416 28. Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai MJ (1997) Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev 11:2323–2334 29.

Gehring WJ, Affolter M, Burglin T (1994) Homeodomain proteins. Annu Rev Biochem 63:487–526 42. Trainor PA, Krumlauf R (2001) Hox genes, neural crest cells and branchial arch patterning. Curr Opin Cell Biol 13:698–705 43. Leonard J, Peers B, Johnson T, Ferreri K, Lee S, Montminy MR (1993) Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. Mol Endocrinol 7:1275–1283 44. Miller CP, McGehee RE Jr, Habener JF (1994) IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene.

The connecting peptide does not prevent proinsulin from selfassociating to form dimers and zinc-stabilized hexamers [24,25]. The typical length of the C-peptide (30–35 amino acids (aa)) is necessary for efficient processing of proinsulin by the prohormone convertases [26] and also may enhance its folding and intracellular transport. , intact proinsulin exhibits 3%–5% of the receptor binding and biologic activity of insulin in vitro [12,27]. Secreted proinsulin and/or intermediate forms do not undergo further cleavage in the circulation or in tissues [28].

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Pancreatic Beta Cell in Health and Disease by Susumu Seino, Graeme I. Bell


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