Read e-book online Pharmacotherapy of Obesity: Options and Alternatives PDF

By Karl G. Hofbauer, Ulrich Keller, Olivier Boss

ISBN-10: 0415303214

ISBN-13: 9780415303217

Drug therapy of weight problems continues to be a arguable subject. critiques diversity from advocating life-long remedy of weight problems with a unmarried drug or drug mixture, to opposing drug therapy of weight problems as a result of its inevitable use as "lifestyle drugs." Clarifying the controversy, Pharmacotherapy of weight problems: suggestions and choices explores present and destiny concepts for drug therapy for weight problems within the context of pathophysiology and medical standards after which places them into point of view opposed to on hand replacement remedies. unusual scientists and scientific investigators offer state of the art reports of every person subject, which covers a variety of matters from pathophysiology of weight problems to some great benefits of weightloss. The middle sections on pharmacotherapy care for at the moment on hand medicinal drugs and medication in pre-clinical improvement, complemented with sections on non-drug therapy and basic healing elements. This layout offers an built-in view of healing methods to the therapy of weight problems and its linked syndromes.

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2000). , 2001). Consequently, the effects of the UCP3 transgene expression were not indicative of a normal physiological function. , 2003). Although no genetic evidence exists for variation in genes encoding ion transporters other than the UCPs, the human genome project has revealed a huge number of genes that could function in thermogenic mechanisms. org/). However, evidence that these mechanisms actually limit the development of obesity by stimulating energy expenditure must be demonstrated.

Ravussin, E. et al. Reduced rate of energy expenditure as a risk factor for body-weight gain. N. Engl. J. Med. 8 (1988): 467–472. Ravussin, E. et al. Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nat. Med. 2 (1997): 238–240. Ravussin, E. Swinburn. Metabolic predictors of obesity: cross-sectional versus longitudinal data. Int J. Obes. Relat. Metab. Disord. 17 Suppl. 3 (1993): S28–31; discussion S41–42. Ravussin, E. et al. Effects of a traditional lifestyle on obesity in Pima Indians.

A brief overview of human energy metabolism and its relationship to essential obesity. Am. J. Clin. Nutr. 1 Suppl. (1992): 242S-245S. Ravussin, E. Bogardus. Relationship of genetics, age, and physical-fitness to daily energyexpenditure and fuel utilization. Am. J. Clin. Nutr. 5 (1989): 968–975. Ravussin, E. et al. Effects of human leptin replacement of food intake and energy metabolism in 3 leptin-deficient adults (Abstract). Int. J. S1 (2002): S136. Ravussin, E. Gautier. Metabolic predictors of weight gain.

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Pharmacotherapy of Obesity: Options and Alternatives by Karl G. Hofbauer, Ulrich Keller, Olivier Boss

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