By Karen Artzt, Jiang I. Wu (auth.), Talila Volk BSc, MSc, PhD, Karen Artzt BA, PhD (eds.)
Talila Volk is an affiliate professor within the box of Developmental Biology and the incumbent of the Sir Ernest B. Chain expert Chair. Her significant study curiosity is in tissue morphogenesis and organogenesis in the course of embryonic improvement. She has been learning the functionality and task of the megastar loved one Held Out Wing (HOW) within the fruit fly Drosophila due to the fact that 1999. She served because the chair for the Society of Developmental Biology in Israel (ISDB). Dr. Volk has received her BSc from Tel‑Aviv college, and her MSc and PhD levels from the Weizmann Institute of technological know-how, Rehovot, Israel. Karen Artzt is an Ashbel Smith Professor Emeritus on the college of Texas at Austin the place she directed a study laboratory for two decades. There she was once a member of the component to Molecular Genetics and Microbiology. sooner than that she used to be an affiliate Member of the Memorial Sloan Kettering melanoma middle in manhattan. Her major learn pursuits contain developmental genetics with an emphasis on melanoma biology. In collaboration with Tom Ebersole she pointed out and cloned the mouse gene quaking that was once one of many founding individuals of the celebrity relations. Dr. Artzt got her educational levels from Cornell college; a BA from the Ithaca campus and a PhD from the scientific collage university of Graduate Sciences in big apple urban. In 1972 she spent a 12 months as a postdoctoral fellow on the Pasteur Institute in Paris below the path of the Nobel Prize winner, Francois Jacob.
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Additional info for Post-Transcriptional Regulation by STAR Proteins: Control of RNA Metabolism in Development and Disease
2009; 4(10): e7440. 24 POST-TRANSCRIPTIONAL REGULATION BY STAR PROTEINS 68. McInnes LA, Lauriat TL. RNA metabolism and dysmyelination in schizophrenia. Neurosci Biobehav Rev 2006; 30:551-561. 69. Aberg K, Saetre P, Jareborg N et al. Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia. Proc Natl Acad Sci USA 2006; 103:7482-7487. 70. Aberg K, Saetre P, Lindholm E et al. Human QKI, a new candidate gene for schizophrenia involved in myelination.
74 Thus Sam68 heterodimers of KH-containing and non-KH-containing forms might tune down its RNA-binding activity. It appears that Qk also has such a splice form,29 however its abundance is not known. Notably, another level of potential tight control for Qk is mediated through its very long and conserved 3vUTRs. , DW WKH mRNA level in different tissues during development. 78,79 Thus the STAR family is like a conductor of an orchestra playing a fugue with peaks and valleys of voices in different tissues—It is possible that the STAR family members STAR TREK: AN INTRODUCTION TO STAR FAMILY PROTEINS AND REVIEW OF QKI 21 DUH PDVWHU UHJXODWRUV RI FDUU\LQJ H[WHUQDO VLJQDOV GLUHFWO\ WR 51$ DQG WKXV DUH HI¿FLHQW at helping to maintain a dynamic and progressive equilibrium during development.
2. Taylor SJ, Shalloway D. An RNA-binding protein associated with src through its SH2 and SH3 domains in mitosis. Nature 1994; 368:867-871. -RQHV $5 6FKHGO 7 0XWDWLRQV LQ JOG D IHPDOH JHUP FHOOVSHFL¿F WXPRU VXSSUHVVRU JHQH LQ FDHQRUKDEGLWLV elegans, affect a conserved domain also found in src-associated protein sam68. Genes Dev 1995; 9:1491-1504. 4. Ebersole TA, Chen Q, Justice MJ et al. The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins.
Post-Transcriptional Regulation by STAR Proteins: Control of RNA Metabolism in Development and Disease by Karen Artzt, Jiang I. Wu (auth.), Talila Volk BSc, MSc, PhD, Karen Artzt BA, PhD (eds.)