By Philip Kumanov, Ashok Agarwal
Bringing jointly the most recent wisdom at the progress and improvement of kids and an important abnormalities of puberty, this finished textual content offers the present perspectives at the pathogenesis, diagnostic probabilities and healing ideas of the most deviations from the conventional process puberty (e.g., precocious and behind schedule puberty). The chain of actual and hormonal alterations within the transitional years is thoroughly undefined, together with the legislation of the hypothalamic pulse generator in addition to the timing of puberty. additional subject matters contain progress disturbances, adolescent varicocele, adolescent gynecomastia, polycystic ovary syndrome, pubertal pimples, and the psychosocial improvement of youth with pubertal abnormalities. Written and edited through across the world famous specialists, Puberty should be a very good source for pediatricians, endocrinologists, gynecologists, andrologists, urologists, relations practitioners, baby psychologists and public health and wellbeing experts – all those that should be challenged of their daily perform with the issues of puberty.
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Extra resources for Puberty: Physiology and Abnormalities
The appearance of pubertal signs in girls less than 8 years is traditionally considered as precocious sexual development, while the lack of breast development by 13 years is a sign of delayed or absent sexual maturation [42, 43]. 42 R. Robeva and P. Kumanov Fig. 1 Breast development in girls. M1–M5 correspond to breast stages B1–B5 in the text. [Reprinted from Biro F, Dorn L. Issues in Measurement of Pubertal Development. In: Preedy VR, editor. Handbook of Anthropometry: Physical Measures of Human Form in Health and Disease.
Sexual differentiation of pituitary function: apparent difference between primates and rodents. Science. 1973;179:484–6. 40. Adams JM, Taylor AE, Schoenfeld DA, Crowley Jr WF, Hall JE. The midcycle gonadotropin surge in normal women occurs in the face of an unchanging gonadotropin-releasing hormone pulse frequency. J Clin Endocrinol Metab. 1994;79:858–64. 41. Filicori M, Santoro N, Merriam GR, Crowley Jr WF. Characterization of the physiological pattern of episodic gonadotropin secretion throughout the human menstrual cycle.
In the ﬁrst months of life, the surge may be linked to FSH-dependent Sertoli cell proliferation . AMH and inhibin B are useful biomarkers of FSH action , as seen in neonates with congenital central hypogonadism . 76) (91–371) 295 (69–1017) 71 (30–423) 10 (4–59) a b Data from  Data from  This postnatal activation of the hypothalamic-pituitary-gonadal axis has been called “mini-puberty” and is reﬂected in subtle clinical changes in the male: Sertoli cell proliferation results in a minor increase in testicular volume, which can only be detected by ultrasonography (reviewed in ), and Leydig cell androgen production has a trophic effect on the genitalia.
Puberty: Physiology and Abnormalities by Philip Kumanov, Ashok Agarwal