By G. Burnstock
Fifty-odd years have elapsed because the first commentary of the reaction of visceral tender muscle to an adenine nucleotide used to be mentioned by way of Drury and Szent Gyorgi (1929). it really is referred to now that purinergic receptors mediating responses to adenosine and the adenine nucleotides (AMP, ADP and ATP) are found in all kinds of visceral tender muscle. Adenine itself and different endogenous purine derivatives seem to have no direct results, or purely minimum results, on such a lot visceral tender muscle groups. Airway gentle muscle is an exception during this regard, and responds to purine bases and non-adenine nucleosides and nucleotides. wisdom of the distribution of purinergic receptor websites at the plasma membrane of visceral musculature has grown quite speedily when you consider that Burnstock and his colleagues (1970) proposed that ATP, or a similar adenine spinoff, is the inhibitory transmitter published from non cholinergic non-adrenergic nerves found in the intestine. a lot proof has been offered favoring the view that ATP is the inhibitory transmitter, and proof on the contrary has additionally been recommend. The speculation is still arguable essentially simply because particular blockers of the postsynaptic purinergic website, with which the speculation will be demonstrated, haven't been discovered. however, the varied reviews designed to enquire the purinergic nerve speculation have generated a lot details in regards to the nature of the purinergic receptors in visceral tender muscle.
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Bennett, M. E. (1964), Int. J. , 3, 163-166. , Satchell, D. and Smythe, A. (1970), Br. J. , 40, 668-688. , Cocks, T. and Crowe, R. (1978), Br. J. , 64, 13-20. , Crowe, R. and Kasakov, L. (1978), Br. J. , 63, 125-138. M. and Staszewska-Barczak, J. (1975), Eur. J. , 31,360-362. , Crowe, R. K. (1979), Br. J. , 65, 377-388. H. and Smythe, A. (1972a), Br. J. G. and Smythe, A. (1972b), Br. J. , 46, 234-242. , Jones, A. ), Edward Arnold, London, pp. 451-495. A. (1979),J. Pharm. , 31, 189-191. M. E. (1974), Surgery, 75,220-227.
1972), Nature, 236, 385-390. J. F. (1975), J. bioi. , 250,5003-5009. H. and Mittenzwei, H. (1957), Arzneim. , 7, 24-59. , Proca, B. G. (1979), Naunyn-Schmiedeber Arch. , 308, 273-279. Braun, S. and Levitzki, A. (1979),Isr. J. Med. , 15,82. , Burnstock, G. and Cocks, T. (1979), Br. J. , 65,97-102. Buchthal, F. and Kahlson, G. (1944), Acta Physiol. , 8,325-334. J. and Spence, I. (1979), Proc. Aust. Physiol. Pharm. , 10, 268P. J. S. (1961),J. Pharm. , 13, 290-299. J. and Gerlach, E. , 358, 2l3-224.
1977), Proc. Roy. , London, 197, 515-520. Dahlquist, R. and Diamant, B. (1970), Acta Pharmacol. , 28, Suppl. 1,43. Daly, J. (1977), In: Cyclic Nucleotides in the Nervous System, Plenum Press, New York. E. and Irwin, J. (1965), Can. J. Physiol. , 43,89-136. , Crowe, R. and Burnstock, G. (1978), Pflug. , 377,43-49. M. W. (1978),Prostaglandin, 16,245-251. J. and Christensen, J. (1976), Ann. Int. , 84,220-221. C. J. (1976),1. , London, 259, 223-237. De Gubareff, T. and Sleator, W. (1965),1. Pharmac.
Purinergic Receptors by G. Burnstock