Download e-book for kindle: Rabbit Biotechnology: Rabbit genomics, transgenesis, cloning by Louis-Marie Houdebine, Jianglin Fan

By Louis-Marie Houdebine, Jianglin Fan

ISBN-10: 9048122260

ISBN-13: 9789048122264

ISBN-10: 9048122279

ISBN-13: 9789048122271

The learn of organic capabilities of proteins and their attainable roles within the pathogenesis of human ailments calls for a growing number of correct animal versions. even supposing mice together with genetically changed mice supply many percentages, different non-murine species are completely required in a few situations. Rabbit is this sort of species, which has been universal in biomedical stories. This animal is genetically and physiologically in the direction of people together with cardiovascular procedure and metabolism features. The rabbit is hence extra acceptable than mice to check a few illnesses corresponding to atherosclerosis and lipid metabolism. as a result of its greater measurement, surgical procedure manipulation, bleeding, and turn-over experiences are a lot more straightforward played in rabbits than in mice. moreover, transgenic rabbits should be produced utilizing microinjection and different equipment resembling lentiviral vectors. Cloning in rabbits has been proved attainable, although nonetheless onerous and time-consuming. confidently, sensible rabbit ES telephone strains could be to be had within the coming years. Gene deletion or knock-out in rabbits will then turn into attainable. at the moment, gene knock down utilizing siRNA or micro RNA is an enticing substitute. The accomplishment of the full rabbit genome sequencing is set to be accomplished. additionally, rabbit is getting used to provide pharmaceutical proteins, together with human polyclonal antibodies. Rabbit can be an important resource of meat in a few nations. those biotechnology tasks, even though very diverse, are utilizing primarily related technical techniques. An optimum program of rabbits calls for development of those assorted thoughts. to interchange the data and replace the complicated know-how in rabbits, the 1st overseas assembly on rabbit biotechnology used to be held in Tsukuba, Japan, in 2005 and by means of the second one assembly in Jouy en Josas (near Paris) on June 14 and 15, 2007. the subsequent assembly has been scheduled in years in Xi’an, China. a selected biotechnology of the rabbit is hence rising. We strongly think that the time has come to collect a latest specialist booklet (tentatively named as Rabbit Biotechnology). This publication goals at confronting different subtle ways constructed independently in numerous educational and commercial laboratories in addition to in a few businesses on the planet.

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Extra info for Rabbit Biotechnology: Rabbit genomics, transgenesis, cloning and models

Sample text

Rabbits consume approximately pellets by 50g/kg body weight. More water is needed for growing animals as well as pregnant and lactating females (Meredith 2000). 2 Behavioral and Sensory Physiology It may be considered that the sight of a rabbit is not good. In visual field of a rabbit, horizontal one is very good, but vertical one is not. They have 180° field of vision, but cannot see area beneath their mouth. A range of stereoscopic vision is very small, so rabbits crash to an obstacle in their front.

Behav. Sci. 24: 157–167. Matsuki T, Cohen MV and Downey JM (1990) Free radical scavengers preserve wall motion in the xanthine oxidase-deficient rabbit heart. Coron. Artery Dis. 1: 383–390. Meredith A (2000) General biology and husbandry. In “Manual of Rabbit Medicine and Surgery”: 13–23. British Small Animal Veterinary Association, London. ” Masson, New York. Morton DB, Jennings M, Batchelor GR, et al. (1993) Refinement in rabbit husbandry. Lab. Anim. 27: 301–329. Myers K, Parer I, Wood D, et al.

Anim. 27: 301–329. Myers K, Parer I, Wood D, et al. (1994) The rabbit in Australia. In “The European Rabbit: The History and Biology: The History and Biology of a Successful Coloniser”: 108–157. Oxford University Press, Oxford. Mykytowycz R (1968) Territorial marking by rabbits. Sci. Am. 218: 116–126. Sanford TD and Colby ED (1980) Effect of xylazine and ketamine on blood pressure, heart rate, and respiratory rate in rabbits. Lab. Anim. Sci. 30: 519–523. Suckow MA, Brammer DW, Rush HG and Chrisp CE (2002) Biology and diseases of rabbits.

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Rabbit Biotechnology: Rabbit genomics, transgenesis, cloning and models by Louis-Marie Houdebine, Jianglin Fan

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