Review of the Environmental Protection Agency's Draft IRIS by National Research Council, Committee to Review EPA's PDF

By National Research Council, Committee to Review EPA's Toxicological Assessment

ISBN-10: 0309150949

ISBN-13: 9780309150941

Tetrachloroethylene is a unstable, chlorinated natural hydrocarbon that's popular as a solvent within the dry-cleaning and textile-processing industries and as an agent for degreasing steel components. it's an environmental contaminant that has been detected within the air, groundwater, floor waters, and soil. In June 2008, the U.S. Environmental security enterprise published its draft Toxicological overview of Tetrachloroethylene (Perchloroethylene) (CAS No. 127-18-4) in aid of precis info at the built-in danger info procedure (IRIS). The draft IRIS overview presents quantitative estimates of melanoma and noncancer results of publicity to tetrachloreothylene, with a view to be used to set up airquality and water-quality criteria to guard public overall healthiness and to set cleanup criteria for harmful waste websites. on the request of EPA, the nationwide examine Council performed an self sustaining clinical evaluate of the draft IRIS review of tetrachloroethylene from toxicologic, epidemiologic, and human medical views. The ensuing booklet evaluates the adequacy of the EPA review, the knowledge and techniques used for deriving the noncancer values for inhalation and oral exposures and the oral and inhalation melanoma unit dangers posed by way of tetrachloroethylene; evaluates even if the most important experiences underlying the draft IRIS review are of considered necessary caliber, reliability, and relevance to aid the derivation of the reference values and melanoma hazards; evaluates no matter if the uncertainties in EPA's threat evaluate have been safely defined and, the place attainable, quantified; and identifies learn that may decrease the uncertainty within the present figuring out of human wellbeing and fitness results linked to tetrachloroethylene publicity.

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Extra resources for Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene

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2003); relatively more TCVC is metablized by the β-lyaseindependent pathway in humans. 3 Neurotoxicity This chapter reviews information presented in the Environmental Protection Agency (EPA) draft Integrated Risk Information System (IRIS) assessment of the effects of tetrachloroethylene on the nervous system. It considers first the human evidence, including an evaluation of EPA’s selection of the most critical study on which to base its reference values, and then the evidence from experimental animal studies.

The process would include a delineation of criteria for selecting studies, approaches for conducting a weight-of-evidence evaluation, and options for dose-response assessment and the characterization of uncertainties. EPA should also consider ways to reorganize the document to streamline presentation of the data and analyses. 15 Summary Uncertainty Analysis EPA’s assessment of tetrachloroethylene follows a traditional approach to developing cancer slope factors and hazard indexes that takes uncertainties into account qualitatively and via uncertainty factors.

Each study was looked at in the light of those factors, and studies were neither chosen nor rejected on the basis of their results. The selection criteria included consideration of the following factors and questions: 30 Neurotoxicity 31  Populations: Are the target and study populations well defined and described? Is the referent group representative of either the unexposed population (in a cross-sectional or cohort design) or of the source population (in a casecontrol design)? Studies with an inappropriate referent population were given less weight.

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Review of the Environmental Protection Agency's Draft IRIS Assessment of Tetrachloroethylene by National Research Council, Committee to Review EPA's Toxicological Assessment


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