Read e-book online RNA Nanotechnology and Therapeutics PDF

By Peixuan Guo, Farzin Haque

ISBN-10: 1299703445

ISBN-13: 9781299703445

Interest in RNA nanotechnology has elevated lately as attractiveness of its power for purposes in nanomedicine has grown. Edited by means of the world's greatest specialists in nanomedicine, this accomplished, state of the art reference information the most recent study advancements and demanding situations within the biophysical and unmarried molecule methods in RNA nanotechnology. furthermore, the textual content additionally offers in-depth discussions of RNA constitution for nanoparticle development, RNA computation and modeling, unmarried molecule imaging of RNA, RNA nanoparticle meeting, RNA nanoparticles in therapeutics, RNA chemistry for nanoparticle synthesis, and conjugation and labeling.

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2 Thermodynamic Instability.................................................................................... 3 Short In Vivo Half-Life.............................................................................................. 4 Low Yield and High Production Costs.................................................................. 5 Toxicity, In Vivo Safety, and Side Effects................................................................ 41 * This chapter is adapted from the full published review article with permission from Mary Ann Liebert, Inc.

2009). , 2005). , 2005). The 3D design, circular permutation, folding energy alteration, and nucleotide modification of RNA were applied to generate RNase-resistant RNA nanoparticles with low toxicity and to ensure processing of the chimeric RNA complexes into siRNA by Dicer after delivery. 5 Challenges and Perspectives RNA nanoparticle construction involves conjugation of functionalities, crosslinking of modules, labeling of subunits, and chemical modification of nucleotides. Methods of synthesizing RNA building blocks include both chemical and enzymatic approaches.

The field of RNA nanotechnology is emerging, but it will play an increasingly important role in medicine, biotechnology, synthetic biology, and nanotechnology. uc. edu/nanomedicine/RNA2010/). The author would like to thank John Rossi, Peter Stockley, Andrew Ellington, Shane Fimbel, Jason Lu, Farzin Haque, Anne Vonderheide, Randall Reif, Chaoping Chen, Mathieu Cinier, and Feng Xiao for their insightful comments and Chad Schwartz, Yi Shu, and Jia Geng for their assistance in the preparation of this manuscript.

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RNA Nanotechnology and Therapeutics by Peixuan Guo, Farzin Haque


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