New PDF release: The Protective Arm of the Renin Angiotensin System

By Thomas Unger, U. Muscha Steckelings, Robson Augusto Souza dos Santos

ISBN-10: 0128013648

ISBN-13: 9780128013649

The protecting Arm of the Renin Angiotensin method: practical points and healing Implications is the 1st accomplished book to sign the protecting position of a different a part of the renin–angiotensin process (RAS), delivering readers with early perception right into a complicated method with a purpose to develop into of significant clinical value within the close to destiny. concentrating on contemporary examine, the protecting Arm of the Renin Angiotensin process offers a bunch of latest experimental reports on particular elements of the RAS, particularly angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert major priceless, health-promoting activities through counterbalancing the well known damaging arm of the RAS with its classical angiotensin AT1 receptor. This leading edge idea of the protecting arm of the RAS, tested during this reference, represents an necessary historical past and should be a robust help for biomedical scholars, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, in addition to the other healthcare professional or researcher involved in RAS body structure, pathophysiology and scientific implications.

  • Provides a whole figuring out of the protecting aspect of the Renin Angiotensin method (RAS) regarding angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor
  • Combines the data of editors who pioneered learn at the protecting renin angiotensin method together with; Dr. Thomas Unger, one of many founders of AT2 receptor learn; Dr. Ulrike M. Steckelings, who contributed considerably to first preclinical stories with a singular particular AT2-agonist, and Dr. Robson Santos who pioneered study on angiotensin-(1-7) and its receptor Mas.
  • Shows that the protecting RAS axes may be able to ameliorate the process numerous cardiovascular, renal, metabolic and neurological diseases
  • Provides the root for the knowledge of a singular healing method of stimulate parts of the protecting arm of the RAS.

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Extra resources for The Protective Arm of the Renin Angiotensin System

Sample text

AT2 receptor and vascular smooth muscle cell differentiation in vascular development. Hypertension 1999;33(6):1414–19. 69. Leung KK, Liang J, Ma MT, Leung PS. Angiotensin II type 2 receptor is critical for the development of human fetal pancreatic progenitor cells into islet-like cell clusters and their potential for transplantation. Stem Cells Dayt 2012;30(3):525–36. 70. Leung KK, Liang J, Zhao S, Chan WY, Leung PS. Angiotensin II type 2 receptor regulates the development of pancreatic endocrine cells in mouse embryos.

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Mol Endocrinol 2014;28(3):281–94. 51. Maurice P, Kamal M, Jockers R. Asymmetry of GPCR oligomers supports their functional relevance. Trends Pharmacol Sci 2011;32(9):514–20. 52. AbdAlla S, Lother H, Abdel-tawab AM, Quitterer U. The angiotensin II AT2 receptor is an AT1 receptor antagonist. J Biol Chem 2001;276(43):39721–6. 53. Dias J, Ferrão FM, Axelband F, Carmona AK, Lara LS, Vieyra A. ANG-(3–4) inhibits renal Na+−ATPase in hypertensive rats through a mechanism that involves dissociation of ANG II receptors, heterodimers, and PKA.

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The Protective Arm of the Renin Angiotensin System by Thomas Unger, U. Muscha Steckelings, Robson Augusto Souza dos Santos


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