By S. Falkner, S. Falkmer, B. Hellman, I. -B. Täljedal
The constitution and Metabolism of the Pancreatic Islets: A Centennial of Paul Langerhans' Discovery is a suite of that provides the development within the box of pancreatic islet examine, really within the region of biosynthesis and secretion of insulin. The name additionally serves as a commemorative fabric to Paul Langerhans' paintings.
The textual content first covers the differentiation and development of the endocrine pancreas, after which proceeds to tackling α- and ß-cells. subsequent, the choice bargains with the glucose metabolism of the pancreatic islets. The textual content additionally discusses the biosynthesis and garage of insulin, besides insulin free up. The 7th half info pancreatic islets and diabetes.
The publication could be of serious use to scholars, researchers, and practitioners of medication.
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Extra resources for The Structure and Metabolism of the Pancreatic Islets. A Centennial of Paul Langerhans' Discovery
103, 275. NATHORST-WINDAHL, G. (1963) Studies on pancreatectomized diabetic rabbits, Acta path, microbiol. , 59, 558. -W. (1968) Die Amitotische Zellteilung. Eine elektronenmikroskopische Untersuchung an Interrenalzellen von Rana temporaria, Z. , 84, 516. , and CARPENT, G. (1963) Über das Vorkommen von Mitosen in den Inselzellen des menschlichen Pankreas, Beiträge zur path. , 128, 335. PRZYBYLSKI, R. J. (1967) Cytodifferentiation of the chick pancreas: I, Ultrastructure of the islet cells and the initiation of granule formation, Gen.
These authors suggest that they are the origin of the gastrin-producing tumours of the pancreas, because they found these cells in cases with the Zollinger-Ellison syndrome. Until now gastrin could not be extracted from the normal pancreas of animals or man, while insulin and glucagon could. This may be due to the fact that the methods used for the identification of gastrin were not sensitive enough. To date we can distinguish at least four well-defined clinical syndromes arising in cases of islet cell tumours which can be cured by tumour extirpation: 1.
Normoglycemic spiny mouse. -cell (B) (left). In the a-cell, several Golgi cisternae ((7) contain maturing secretory granules. In the ß-cell, pale and dense granules are seen, as well as two vesicles containing rectangular shaped granules (arrows). N = nuc leus; Ca = capillary. ) & &'-SSV Vt tiv-w FIG. 4. Severely diabetic spiny mouse. i and B2) con taining varying amount of glycogen. 2 several vesicles with content of low electron density. The arrow indicates one vesicle containing a charac teristic rectangular shaped structure.
The Structure and Metabolism of the Pancreatic Islets. A Centennial of Paul Langerhans' Discovery by S. Falkner, S. Falkmer, B. Hellman, I. -B. Täljedal