New PDF release: Toxicological profiles - Phenol

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Body weight effects were not observed in adult female Harlan Wistar rats exposed to an aerosol containing 234 ppm phenol for 8 hours (Flickinger 1976), nor in rats exposed continuously to 26 ppm phenol in air for 15 days (Dalin and Kristoffersson 1974), nor in rhesus monkeys, rats, or mice exposed continuously to 5 ppm phenol in air for 90 days (Sandage 1961). Other Systemic Effects. Dalin and Kristoffersson (1974) reported elevated serum concentrations of potassium and magnesium in rats exposed to 26 ppm phenol vapor continuously for 15 days.

The urine tested negative for protein and urobilinogen. The urine cleared 2–3 months after removal from exposure. Although the exposure concentrations were not reported, the study author stated that heavy odors were often detectable, and that phenol was often spilled on the patient’s clothes resulting in skin irritation. Since phenol is absorbed readily from the skin, dermal absorption may have contributed to the systemic effects that were observed. Renal proximal tubule and glomerular injury was reported in guinea pigs exposed by inhalation to 26–52 ppm phenol for 41 days, and rabbits exhibited qualitatively similar but less severe effects after 88 days of similar exposure (Deichmann et al.

Which is a widely used liquid wood preservative. It should be noted that in the report, Ksylamit™ is indicated to consist of “ . . a mixture of chlorinated benzenes, pentachlorophenol, alphachloronaphthalene, chloroparaffin and kerosene . . ”, and that the authors provide no discussion of how phenol and formaldehyde are produced through the use of such a mixture. Twenty-two workers (18 women and 4 men) exposed for at least 6 months were the cases, and 29 non-exposed, non-smoking volunteers matched for age, sex, and place of residence were the controls.

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